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Renin activity, concentration, substrate and reactivity were determined in normal subjects as well as in hypertensive subjects with suppressed and normal plasma renin activity. Renin substrate measurements were similar in all groups. Renin reactivity, a measure of circulating modifiers of the renin reaction, was significantly increased in both hypertensive groups. Reactivity was significantly greater in the normal renin hypertensive group than the low renin hypertensive group. Renin concentration was significantly suppressed in both hypertensive groups, but to a greater degree in the low renin hypertensives. These findings suggest that plasma renin concentration may be suppressed in most hypertensive subjects. Furthermore, plasma renin activity may be "normalized" in most hypertensive subjects by the effect of circulating modifiers of the renin reaction. While renin reactivity in the plasma of low-renin hypertensive subjects is accelerated to a lesser degree than that of the normal-renin hypertensives, this finding alone does not explain the low plasma renin activity.
W J McDonald, and
E L Cohen, and
J W Conn
February 1977,
The Journal of clinical endocrinology and metabolism,
W J McDonald, and
E L Cohen, and
J W Conn
August 1976,
Circulation research,
W J McDonald, and
E L Cohen, and
J W Conn
May 1979,
Circulation,
W J McDonald, and
E L Cohen, and
J W Conn
March 1976,
Circulation,
W J McDonald, and
E L Cohen, and
J W Conn
July 1977,
Clinical pharmacology and therapeutics,
W J McDonald, and
E L Cohen, and
J W Conn
January 1977,
Clinical pharmacology and therapeutics,
W J McDonald, and
E L Cohen, and
J W Conn
March 1975,
The Journal of clinical endocrinology and metabolism,
W J McDonald, and
E L Cohen, and
J W Conn
January 1978,
Endokrynologia Polska,
W J McDonald, and
E L Cohen, and
J W Conn
May 1978,
Japanese circulation journal,
W J McDonald, and
E L Cohen, and
J W Conn
August 1983,
Endocrinologia japonica,
