-transparent.png){kind=logo}
The effect of intracerebroventricular (i.c.v.) treatment with antisense oligodeoxynucleotide (A-oligo) to delta opioid receptor mRNA on cocaine-induced place preference was examined in mice. Cocaine (10 mg/kg, s.c.) produced a significant place preference. I.c.v. treatment with A-oligo (0.001-1 microg/mouse) dose-dependently attenuated the cocaine (10 mg/kg, s.c.)-induced place preference, although mismatched oligodeoxynucleotide (1 microg/mouse, i.c.v.) was ineffective. In the present study, we found that the selective reduction in number and/or function of central delta opioid receptors by A-oligo suppresses the cocaine-induced place preference. These results suggest that the conditioned reward by cocaine may be partially mediated by central delta opioid receptors.
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
September 1994,
Japanese journal of pharmacology,
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
October 1995,
Regulatory peptides,
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
September 1995,
European journal of pharmacology,
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
January 1994,
Life sciences,
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
October 2006,
Neuroscience,
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
April 1992,
Japanese journal of pharmacology,
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
June 1994,
European journal of pharmacology,
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
August 1992,
European journal of pharmacology,
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
March 1997,
The Journal of pharmacology and experimental therapeutics,
T Suzuki, and
M Tsuji, and
H Ikeda, and
M Misawa, and
M Narita, and
L F Tseng
February 1995,
European journal of pharmacology,
