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OBJECTIVE The correlation between the serum soluble interleukin-2 receptor (SIL-2R) levels and clinical stage is demonstrable in a variety of non-Hodgkin lymphomas. The prognostic significance of sIL-2R levels in the serum of patients with renal cell carcinoma (RCC) was investigated. METHODS sIL-2R were measured in patients with RCC (n=39) and normal control (n=6) by the enzyme immunoassay technique. Cases of RCC were classified according to the clinical stage, pathological grade and growth type. The IL-2R expression of RCC was evaluated by RT-PCR. RESULTS The serum sIL-2R levels of patients with RCC showed significantly higher values than those of controls (p < 0.05). The serum sIL-2R levels in RCC were closely associated with the stage, grade and growth type of disease. The patients with high serum sIL-2R level (> = 1,000 U/L) exhibited a significantly poorer prognosis than those with low serum sIL-2R level (<1,000 U/L). The band of IL-R was detected only by using the template from the mRNA extracted from a resected tumor tissue of the RCC but not from the RCC cell lines. CONCLUSIONS It was suggested that the measurement of serum sIL-2R levels is useful for predicting the prognosis.
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
January 2004,
Clinical transplantation,
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
January 1993,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
December 1994,
Journal of endocrinological investigation,
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
January 2004,
Annals of clinical and laboratory science,
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
April 1992,
Bollettino della Societa italiana di biologia sperimentale,
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
January 2004,
Roczniki Akademii Medycznej w Bialymstoku (1995),
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
January 1990,
Zeitschrift fur Rheumatologie,
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
June 1996,
Rinsho byori. The Japanese journal of clinical pathology,
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
February 1995,
Clinical transplantation,
K Akiyama, and
M Tsuji, and
Y Kurokawa, and
K Yokota, and
K Kojima, and
S Naruo, and
H O Kanayana, and
S Kagawa
August 1990,
Transplantation proceedings,
