-transparent.png){kind=logo}
A case of autoimmune thyroiditis after long term treatment with lithium is described in a 29 year old Japanese woman with manic depression. Positive serum antithyroglobulin and antimicrosomal antibodies, diffuse goitre, and microscopic chronic thyroiditis, as well as the clinical history of long term lithium treatment were suggestive of lithium associated autoimmune thyroiditis. Microscopically, there was a mild degree of interstitial fibrosis and a moderate degree of lymphocytic infiltration. Some areas showed a moderate degree of stromal fibrosis and atrophic thyroid follicles. Lymphoid follicles with germinal centres, disrupted thyroid follicles with lymphocytic infiltration, and Hürthle cells were also observed. The differential diagnosis in patients presenting with these histological features includes painless (silent) thyroiditis, autoimmune thyroiditis and lithium associated autoimmune thyroiditis. A detailed clinical history is essential if the correct diagnosis is to be reached.
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
January 2002,
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
June 1993,
The Australian and New Zealand journal of psychiatry,
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
October 2005,
Thyroid : official journal of the American Thyroid Association,
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
October 2016,
Journal of child and adolescent psychopharmacology,
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
November 1985,
The American journal of psychiatry,
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
October 2013,
The Australian and New Zealand journal of psychiatry,
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
January 1987,
La Revue de medecine interne,
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
June 2005,
The Korean journal of internal medicine,
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
January 2004,
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia,
M Shimizu, and
M Hirokawa, and
T Manabe, and
K Shimozuma, and
H Sonoo, and
T Harada
January 2011,
Journal of pediatric endocrinology & metabolism : JPEM,
