Effect of aging on the gastrointestinal tract and the pancreas. 1997

A P Majumdar, and R Jaszewski, and M A Dubick
Division of Gastroenterology, VA Medical Center, Detroit, MI 48201, USA.

With estimates that about 14% of the U.S. population will be over 65 years old by the end of this century, scientific research has attempted to achieve a better understanding of the aging process and of diseases that are expressed in higher incidence with advancing age. Because of its high rate of cell turnover and continual renewal, the mucosa of the gastrointestinal (GI) tract appears particularly susceptible to age-related disruptions in the normal cell proliferative process. This may translate into altered function that may result in the induction of malnutrition or malabsorption of particular nutrients, or a greater incidence of GI diseases, such as neoplasia. This review will examine the evidence for age-related alterations in the structural and functional properties of different regions of the GI tract and the pancreas, and how they may relate to malnutrition or disease processes.

UI MeSH Term Description Entries
D007421 Intestine, Small The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM. Small Intestine,Intestines, Small,Small Intestines
D010179 Pancreas A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D003106 Colon The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. Appendix Epiploica,Taenia Coli,Omental Appendices,Omental Appendix,Appendices, Omental,Appendix, Omental
D004068 Digestive System Physiological Phenomena Properties and processes of the DIGESTIVE SYSTEM as a whole or of any of its parts. Digestive Physiology,Digestive System Processes,Digestive System Phenomena,Digestive System Phenomenon,Digestive System Physiological Concepts,Digestive System Physiological Phenomenon,Digestive System Physiology,Digestive System Process,Physiology, Digestive,Phenomena, Digestive System,Phenomenas, Digestive System,Phenomenon, Digestive System,Physiology, Digestive System,Process, Digestive System,Processes, Digestive System
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

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