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Rhizopus nigricans (Rn) is one of the most common members of the Mucorales that produces opportunistic infections and hypersensitivity states. Data concerning experimental induction in guinea pigs of hypersensitivity pneumonitis with a glycoprotein antigen are presented. This antigen was obtained from the mycelial and metabolic products of the cultures and was aerosolized during 12 weeks. The presence of specific antibodies (IgG and/or IgE) was detected by serological techniques; histopathological studies of the lungs showed interstitial infiltrates of macrophages and LTCD8+ cells, as revealed by the MoAb used. Single non-necrotizing granulomas were characteristic from the tenth week to the end of the experiment. The results from this animal model suggest that hypersensitivity pneumonitis is a typical delayed-type reaction due to chronic contact with the heterologous glycoprotein of Rn. The relation of Rn antigen and the development of occupational diseases of the lung such as malt-worker's lung and wood-trimmer's disease is proposed and discussed.
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S R Rodríguez, and
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K Mouchián, and
J F Albónico, and
S G Irañeta
January 1992,
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A Alonso, and
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K Mouchián, and
J F Albónico, and
S G Irañeta
January 2003,
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S G Irañeta
April 1985,
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S G Irañeta
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A Alonso, and
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S M Rodríguez, and
K Mouchián, and
J F Albónico, and
S G Irañeta
January 1973,
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A Alonso, and
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January 1969,
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A Alonso, and
S R Rodríguez, and
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K Mouchián, and
J F Albónico, and
S G Irañeta
January 1990,
Ophthalmic research,
A Alonso, and
S R Rodríguez, and
S M Rodríguez, and
K Mouchián, and
J F Albónico, and
S G Irañeta
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A Alonso, and
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K Mouchián, and
J F Albónico, and
S G Irañeta
August 1965,
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A Alonso, and
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J F Albónico, and
S G Irañeta
October 1993,
The European respiratory journal,
