Under study were the frequency of occurrence and causes of development of the syndrome of low cardiac output after the saving correction of mitral defects under conditions of cranio-cerebral (1st group-80 patients), general moderate (2nd group-130 patients) and deep hypothermia (open mitral commissurotomy-3rd group of 134 patients and reconstructive operations on the mitral valve-4th group of 104 patients). Frequency of development of the complication was reliably higher in groups with deep hypothermia (1.25% of patients in the 1st group, 9.2% in the 2nd group, 27.6% in the 3rd group, 25% in the 4th group). Factors influencing the development of the low cardiac output syndrome in patients of the 2nd group was duration of the disease, in the 3rd group patients-the class according to the classification of the New York cardiological association and age of the patient, in operated patients of the 4th group it was the value of the cardio-pulmonary coefficient. Pharmaco-ice-chip cardioplegia used in patients of the 3rd and 4th groups failed to decrease frequency of the development of the low cardiac output syndrome in the postoperative period.