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ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi. 1997
I Paek, and
L Orci, and
M Ravazzola, and
H Erdjument-Bromage, and
M Amherdt, and
P Tempst, and
T H Söllner, and
J E Rothman
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York 10021, USA.
We report the identification and characterization of ERS-24 (Endoplasmic Reticulum SNARE of 24 kD), a new mammalian v-SNARE implicated in vesicular transport between the ER and the Golgi. ERS24 is incorporated into 20S docking and fusion particles and disassembles from this complex in an ATP-dependent manner. ERS-24 has significant sequence homology to Sec22p, a v-SNARE in Saccharomyces cerevisiae required for transport between the ER and the Golgi. ERS-24 is localized to the ER and to the Golgi, and it is enriched in transport vesicles associated with these organelles.
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