BIOMAT Database Logo BIOMAT Database Logo

Chromosomal localization of the human and mouse hyaluronan synthase genes. 1997

A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Arizona 85259, USA. spicer@mayo.edu

We have recently identified a new vertebrate gene family encoding putative hyaluronan (HA) synthases. Three highly conserved related genes have been identified, designated HAS1, HAS2, and HAS3 in humans and Has1, Has2, and Has3 in the mouse. All three genes encode predicted plasma membrane proteins with multiple transmembrane domains and approximately 25% amino acid sequence identity to the Streptococcus pyogenes HA synthase, HasA. Furthermore, expression of any one HAS gene in transfected mammalian cells leads to high levels of HA biosynthesis. We now report the chromosomal localization of the three HAS genes in human and in mouse. The genes localized to three different positions within both the human and the mouse genomes. HAS1 was localized to the human chromosome 19q13.3-q13.4 boundary and Has1 to mouse Chr 17.HAS2 was localized to human chromosome 8q24.12 and Has2 to mouse Chr 15. HAS3 was localized to human chromosome 16q22.1 and Has3 to mouse Chr 8. The map position for HAS1 reinforces the recently reported relationship between a small region of human chromosome 19q and proximal mouse chromosome 17. HAS2 mapped outside the predicted critical region delineated for the Langer-Giedion syndrome and can thus be excluded as a candidate gene for this genetic syndrome.

UI MeSH Term Description Entries
D008565 Membrane Proteins Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors. Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D002885 Chromosomes, Human, Pair 16 A specific pair of GROUP E CHROMOSOMES of the human chromosome classification. Chromosome 16
D002888 Chromosomes, Human, Pair 19 A specific pair of GROUP F CHROMOSOMES of the human chromosome classification. Chromosome 19
D002898 Chromosomes, Human, Pair 8 A specific pair of GROUP C CHROMOSOMES of the human chromosome classification. Chromosome 8
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000076002 Hyaluronan Synthases Membrane-associated glucuronosyltransferases that catalyze the reaction of UDP-N-acetyl-D-glucosamine and UDP-D-glucuronate to produce HYALURONAN. HYALURONAN SYNTHASE 2 (HAS2) is essential for embryogenesis and its expression by tumor cells is associated with metastasis. HAS1 Protein,HAS2 Protein,HAS3 Protein,Hyaluronan Synthase,Hyaluronan Synthase 1,Hyaluronan Synthase 2,Hyaluronan Synthase 3,Hyaluronan Synthetase,Hyaluronate Synthase,Hyaluronate Synthetase,Hyaluronic Acid Synthetase,hasA Enzyme,3, Hyaluronan Synthase,Protein, HAS3,Synthase 1, Hyaluronan,Synthase 2, Hyaluronan,Synthase 3, Hyaluronan,Synthase, Hyaluronan,Synthase, Hyaluronate,Synthases, Hyaluronan,Synthetase, Hyaluronan,Synthetase, Hyaluronate,Synthetase, Hyaluronic Acid
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D013045 Species Specificity The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species. Species Specificities,Specificities, Species,Specificity, Species

Related Publications

A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Chromosomal localization of mouse and human neurotensin receptor genes.
May 1994, Mammalian genome : official journal of the International Mammalian Genome Society,
A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes.
November 1998, Genomics,
A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Structural comparison and chromosomal localization of the human and mouse IL-13 genes.
June 1993, Journal of immunology (Baltimore, Md. : 1950),
A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Chromosomal localization of Cd1d genes in the mouse.
January 1991, Somatic cell and molecular genetics,
A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.
June 1992, Journal of immunology (Baltimore, Md. : 1950),
A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Chromosomal localization of mouse hair keratin genes.
December 1991, Annals of the New York Academy of Sciences,
A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Prospects for the chromosomal localization of human genes in human-mouse somatic cell hybrids.
January 1969, The Wistar Institute symposium monograph,
A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Structure and chromosomal localization of the human and mouse muscle fructose-1,6-bisphosphatase genes.
April 2000, Gene,
A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes.
March 1997, Oncogene,
A P Spicer, and M F Seldin, and A S Olsen, and N Brown, and D E Wells, and N A Doggett, and N Itano, and K Kimata, and J Inazawa, and J A McDonald
Chromosomal localization of human collagen genes.
June 1987, Collagen and related research,
Copied contents to your clipboard!