BIOMAT Database Logo BIOMAT Database Logo

Helicobacter pylori infection accelerates gene expression of glicentin in the gastric mucosa. Its association with intestinal metaplasia of the stomach. 1997

S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Second Dept. of Internal Medicine, Shimane Medical University, Japan.

BACKGROUND Glicentin is an intestinal polypeptide hormone which seems to promote intestinal metaplasia (IM) in the gastric mucosa. The aim of this study was to clarify whether Helicobacter pylori infection accelerates glicentin gene expression. METHODS Glicentin mRNA was investigated by reverse-transcription polymerase chain reaction using gastric biopsies from 47 patients examined endoscopically and denying IM. RESULTS IM was observed in 18 (38.3%) cases histologically, but not in the other 29 (62.7%). Glicentin mRNA was significantly correlated with histological IM (P < 0.01) and was positively correlated with H. pylori infection (P < 0.05). CONCLUSIONS Our results indicate that H. pylori infection is associated with the induction of glicentin in the gastric mucosa, thus supporting the hypothesis that H. pylori infection accelerates IM of the stomach.

UI MeSH Term Description Entries
D008297 Male Males
D008679 Metaplasia A condition in which there is a change of one adult cell type to another similar adult cell type.
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010446 Peptide Fragments Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques. Peptide Fragment,Fragment, Peptide,Fragments, Peptide
D011498 Protein Precursors Precursors, Protein
D004386 Duodenum The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers. Duodenums
D004763 Glucagon-Like Peptides Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms. Enteroglucagon,Enteroglucagons,Glucagon-Like Peptide,Glucagon-Like Polypeptide,Gut Glucagon,Glucagon-Like Polypeptides,Glucagon Like Peptide,Glucagon Like Peptides,Glucagon Like Polypeptide,Glucagon Like Polypeptides,Glucagon, Gut,Peptide, Glucagon-Like,Polypeptide, Glucagon-Like
D004947 Esophagus The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
D005260 Female Females
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland

Related Publications

S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Helicobacter pylori and intestinal metaplasia of gastric mucosa.
January 1997, Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology,
S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Alteration of E-cadherin expression in gastric mucosa: role of intestinal metaplasia and Helicobacter pylori infection.
January 2004, Anticancer research,
S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Helicobacter pylori in areas of intestinal metaplasia in gastric antral mucosa.
August 1997, Pathology,
S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Gastric metaplasia and Helicobacter pylori infection in intestinal tuberculosis.
January 1994, Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology,
S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Gastric atrophy and intestinal metaplasia in Helicobacter pylori infection.
May 2004, Journal of pediatric gastroenterology and nutrition,
S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Cytotoxin-associated gene A-positive Helicobacter pylori infection in the elderly. Association with gastric atrophy and intestinal metaplasia.
January 1998, Journal of clinical gastroenterology,
S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Cyclooxygenase-2 expression in early gastric cancer, intestinal metaplasia and Helicobacter pylori infection.
April 2002, European journal of gastroenterology & hepatology,
S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
p53 expression in gastric mucosa with Helicobacter pylori infection.
February 1998, Journal of gastroenterology and hepatology,
S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Association of Helicobacter pylori infection with atrophic gastritis and intestinal metaplasia.
October 2000, Journal of gastroenterology and hepatology,
S Ishihara, and R Fukuda, and N Moriyama, and N Ishimura, and T Kaji, and Y Kushiyama, and K Amano, and K Hirakawa, and Y Amano, and K Adachi, and N Ashizawa, and S Fukumoto
Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia.
May 2009, Digestive diseases and sciences,
Copied contents to your clipboard!