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Methyl tertiary-butyl ether (MTBE) is one of the highest production volume chemicals in the USA. Previous results from in vitro genetic toxicity studies suggested that it was not mutagenic. However, chronic exposure at high levels resulted in liver tumors in female mice and kidney tumors in male rats. The current program assessed in vivo genotoxicity and also explored the possibility that a mutagenic mechanism was involved in the carcinogenic process. The specific tests used included the Drosophila sex-linked-recessive-lethal test, the rat bone marrow cytogenetics test, the mouse bone marrow micronucleus test and the in vivo-in vitro hepatocyte unscheduled DNA synthesis test in the mouse. All tests produced negative results, indicating that the potential for in vivo mutagenic activity was low. These data also suggest that the tumorigenic activity was probably the result of a non-genotoxic process.
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
January 2000,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
January 1985,
Gastroenterology,
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
May 2001,
American journal of industrial medicine,
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
April 2006,
Critical reviews in toxicology,
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
February 1988,
Gut,
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
December 2002,
Annals of the New York Academy of Sciences,
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
January 2005,
Mutation research,
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
January 1995,
Archives of environmental health,
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
October 2005,
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,
R H McKee, and
J S Vergnes, and
J B Galvin, and
J F Douglas, and
J J Kneiss, and
L S Andrews
September 1998,
Wei sheng yan jiu = Journal of hygiene research,
