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The antinociceptive effect of purine nucleotides administered systematically (sc) was determined using the formalin and writhing tests in adult male albino mice. The mechanisms underlying nucleotide-induced antinociception were investigated by preinjecting the animals (sc) with specific antagonists for opioid (naloxone, 1 mg/kg), purinergic P1 (caffeine, 5, 10, of 30 mg/kg); theophylline, 10 mg/kg) or purinergic P2 receptors (suramin, 100 mg/kg; Coomassie blue, 30-300 mg/kg; quinidine, 10 mg/kg). Adenosine, adenosine monophosphate (AMP), diphosphate (ADP) and triphosphate (ATP) caused a reduction in the number of writhes and in the time of licking the formalin-injected paw. Naloxone had no effect on adenosine- or adenine nucleotide-induced antinociception. Caffeine (30 mg/kg) and theophylline (10 mg/kg) reversed the antinociceptive action of adenosine and adenine nucleotide derivatives in both tests. P2 antagonists did not reverse adenine nucleotide-induced antinociception. These results suggest that antinociceptive effect of adenine nucleotides is mediated by adenosine.
C F Mello, and
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R E Jimenez-Bernal, and
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R Frussa-Filho
September 1976,
Bollettino della Societa italiana di biologia sperimentale,
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F P Lopes, and
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October 1967,
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R Frussa-Filho
January 1977,
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R Frussa-Filho
July 1955,
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C F Mello, and
J Begnini, and
D D De-La-Vega, and
F P Lopes, and
C C Schwartz, and
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R Frussa-Filho
November 1994,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
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F P Lopes, and
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January 1968,
Progress in industrial microbiology,
C F Mello, and
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July 1992,
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C F Mello, and
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January 1961,
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C F Mello, and
J Begnini, and
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December 1973,
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