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[The approximation of cell distribution by the number of aberrations in the fractionated gamma-neutron irradiation of a human lymphocyte culture at the presynthesis stage (the G0 and G1 stages of the cycle) based on a theoretical model]. 1997

O V Pozdyshkina

A theoretical model is suggested that allows calculating a yield of cells with a number of aberrations caused by fractionated gamma irradiation using the corresponding data for a separate irradiation. The value of a cytogenetic interaction of damages induced by two fractions of irradiation doses was used as a free parameter of the model. In terms of the model, approximation of experimental functions of the cell distribution in a number of exchange aberrations caused by gamma and/or neutron irradiation was made. At a stage G0, with the 1 h interval between the dose fractions, approximation was successful only for irradiation with equal or isoeffective dose fractions; with the interval of 5 h, it was successful for all types of irradiation except for two highest doses of fractionated neutron and gamma/neutron irradiation. At a stage G1, approximation was satisfactory almost for all types of fractionated gamma/neutron irradiation irrespective of the interval between the dose fractions and of a dose of fractionated gamma irradiation with the interval 1 h. For the fractionated neutron and neutron/gamma irradiation at a stage G1, approximation of experimental distributions was unsatisfactory in all the cases.

UI MeSH Term Description Entries
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008433 Mathematics The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Mathematic
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D005214 Fast Neutrons Neutrons, the energy of which exceeds some arbitrary level, usually around one million electron volts. Fast Neutron,Neutron, Fast,Neutrons, Fast
D005720 Gamma Rays Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source. Gamma Wave,Gamma Radiation,Nuclear X-Rays,Radiation, Gamma,X-Rays, Nuclear,Gamma Radiations,Gamma Ray,Gamma Waves,Nuclear X Rays,Nuclear X-Ray,Ray, Gamma,Wave, Gamma,Waves, Gamma,X Rays, Nuclear,X-Ray, Nuclear
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D016192 Resting Phase, Cell Cycle A quiescent state of cells during G1 PHASE. G0 Phase,G0 Phases,Phase, G0,Phases, G0

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