-transparent.png){kind=logo}
Netivudine is a nucleoside analogue with potent anti-varicella zoster virus activity. We now report two open studies of the pharmacokinetics and tolerability of netivudine in doses of 50, 100 and 200 mg twice daily. In one study, healthy volunteers received an initial, single dose followed, a week later, by repeat dosing for 9 1/2 days; in the other, patients with shingles were treated for 8 days and data were also recorded for rash resolution and pain duration and intensity. Netivudine was well tolerated in both studies. Plasma concentrations were similar in patients and healthy volunteers and increased in proportion to dose. Steady state concentrations were 15-25% lower than expected from single dose data, probably because of slightly decreased netivudine absorption after food. Elimination half-life was l4-20 h. Plasma concentrations of 5-propynyluracil (5-PU), the main metabolite of netivudine, did not increase in proportion to the netivudine dose and tended to be higher in patients than volunteers. 5-PU concentrations remained elevated for up to 72 h after the last netivudine dose, suggesting continued but slow release from unabsorbed netivudine in the gut lumen. New lesion formation ceased and vesicles crusted most quickly in the 200 mg group; zoster-associated pain intensity, was reduced in a dose-related manner.
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
May 1996,
The Journal of antimicrobial chemotherapy,
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
January 2014,
Nursing standard (Royal College of Nursing (Great Britain) : 1987),
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
December 2003,
Professional nurse (London, England),
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
November 1983,
Lancet (London, England),
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
August 2006,
Expert review of vaccines,
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
January 2010,
Antiviral chemistry & chemotherapy,
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
January 2009,
Annals of clinical and laboratory science,
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
June 2005,
Medizinische Monatsschrift fur Pharmazeuten,
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
January 2006,
MMW Fortschritte der Medizin,
R W Peck, and
P Crome, and
M J Wood, and
M W McKendrick, and
B Bannister, and
B K Mandal, and
R J Crooks
April 2016,
Revue medicale suisse,
