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Diabetic retinopathy remains a major cause of loss of vision. The Diabetes Control and Complications Trial (DCCT) has implicated hyperglycaemia as a probable major direct causative factor in the pathogenesis of diabetic retinopathy. There are several plausible mechanisms by which high glucose concentrations could lead to the functional and later structural changes characterising diabetic retinopathy. These include increased activity of the aldose reductase pathway, increase de novo synthesis of diacylglycerol from glucose, causing protein kinase C activation, increased non-enzymatic glycation and increased oxidative damage. The demonstration of the potential roles of these pathways and the subsequent effects of growth factors in enhancing angiogenesis provide potential new approaches to the prevention and treatment of diabetic retinopathy.
R G Larkins, and
M E Dunlop, and
E I Johnson
August 1988,
Australian and New Zealand journal of ophthalmology,
R G Larkins, and
M E Dunlop, and
E I Johnson
January 1967,
Transactions of the Ophthalmological Society of Australia,
R G Larkins, and
M E Dunlop, and
E I Johnson
December 1966,
The Medical journal of Australia,
R G Larkins, and
M E Dunlop, and
E I Johnson
April 1952,
The Medical journal of Australia,
R G Larkins, and
M E Dunlop, and
E I Johnson
January 1967,
American journal of ophthalmology,
R G Larkins, and
M E Dunlop, and
E I Johnson
January 1970,
Journal of medical education,
R G Larkins, and
M E Dunlop, and
E I Johnson
August 1928,
Canadian Medical Association journal,
R G Larkins, and
M E Dunlop, and
E I Johnson
March 2009,
Clinical & experimental ophthalmology,
R G Larkins, and
M E Dunlop, and
E I Johnson
April 2004,
The British journal of ophthalmology,
R G Larkins, and
M E Dunlop, and
E I Johnson
January 1974,
Transactions of the Pacific Coast Oto-Ophthalmological Society annual meeting,
