-transparent.png){kind=logo}
The effect of lidocaine on the atrial fibrillation threshold (AFT) and the ventricular fibrillation threshold (VFT) was studied in anesthetized dogs. In ten animals, injection of lidocaine 2 mg./Kg. intravenously resulted in a markded increase of the ventricular fibrillation threshold (from 11.0 +/- 1.5 to 33.3 +/- 6.2 mA., P less than 0.001). In another group of ten animals, lidocaine did not have consistent effect on the atrial fibrillation threshold. However, a dose of lidocaine of 3 mg./Kg intravenously produced a significant increase in AFT (from 14.0 +/- 0.56 to 41.1 +/- 0.32 mA., P less than 0.001). No changes in AFT or VFT were noted in control experiments. The data suggest that lidocaine possesses an antiarrhythmic effect on the atria but higher than usual doses are required.
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
August 1993,
Kokyu to junkan. Respiration & circulation,
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
September 1977,
Angiology,
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
January 2001,
Annali dell'Istituto superiore di sanita,
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
January 1969,
Medicina,
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
August 1972,
The American journal of cardiology,
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
July 1978,
The American journal of cardiology,
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
August 2002,
Pacing and clinical electrophysiology : PACE,
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
May 1993,
Japanese heart journal,
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
May 2001,
Pacing and clinical electrophysiology : PACE,
J B Kostis, and
M J Goodking, and
S Gotzoyannis, and
N H Gerber, and
P T Kuo
July 1972,
Circulation,
