-transparent.png){kind=logo}
Free-flow micropuncture and clearance studies were performed to evaluate the transport of allantoin inthe rat kidney. Inn all studies [2-14C]uric acid and [methoxy-3H]inulin were administered. With a two-step column chromatographic technique, radiolabeled uric acid and allantoin were separated in plasma, urine, and tubular fluid, and the [2-14C]allantoin concentration was determined. Tubular fluid collections were obtained under hydropenic and control coneated animals in the control and volume-expanded states. Clearance data were obtained in oxonic acid-treated animals under the same experimental conditions. These studies indicate that allantoin is not bound to plasma protein and is, therefore, freely filterable. Neither net reabsorption nor net secretion of allantoin was evident along the length of the nephron. The bubular handling of allantoin was demonstrated to be dissociated from that of uric acid in all experimental states. No significant intrarenal production of allantoin from uric acid was observed.
J P Briggs, and
M F Levitt, and
R G Abramson
September 1968,
The Journal of laboratory and clinical medicine,
J P Briggs, and
M F Levitt, and
R G Abramson
June 1975,
Pflugers Archiv : European journal of physiology,
J P Briggs, and
M F Levitt, and
R G Abramson
January 1976,
Physiologia Bohemoslovaca,
J P Briggs, and
M F Levitt, and
R G Abramson
February 1986,
European journal of clinical investigation,
J P Briggs, and
M F Levitt, and
R G Abramson
April 1964,
The American journal of physiology,
J P Briggs, and
M F Levitt, and
R G Abramson
January 1987,
Journal of cardiovascular pharmacology,
J P Briggs, and
M F Levitt, and
R G Abramson
January 1991,
Experimental physiology,
J P Briggs, and
M F Levitt, and
R G Abramson
March 1983,
The American journal of physiology,
J P Briggs, and
M F Levitt, and
R G Abramson
August 1976,
The American journal of physiology,
J P Briggs, and
M F Levitt, and
R G Abramson
December 1965,
Archives of surgery (Chicago, Ill. : 1960),
