Biomaterial Database

Ipronidazole in the drinking water for treatment and prevention of experimental swine dysentery. 1977

L D Olson

The addition of ipronidazole to drinking water at concentrations of 50 and 100 mg/L was effective for treatment of experimentally induced swine dysentery in swine because diarrhea receded in most swine within several days after the drug was added. Medicated swine given these concentrations of drug had fewer days of nonhemorrhagic and hemorrhagic diarrhea, higher feed and water consumption, greater body weight gain,and a more favorable feed efficiency than did the nonmedicated, exposed swine. Medicated swine given dosage of 25 mg/L of drinking water had greater frequency of nonhemorrhagic and hemorrhagic diarrhea than did those given the higher concentrations, and diarrhea in some swine did not subside during medication. All medicated swine survived; in contrast, 90% mortality occurred in the nonmedicated swine. In all groups of medicated exposed swine, occasionally there was recurrence of diarrhea.

UI	MeSH Term	Description	Entries
D007491	Ipronidazole	An antihistomonal agent with low toxicity. It also promotes growth and feed utilization in poultry.
D009593	Nitroimidazoles	IMIDAZOLES having a nitro moiety.	Nitroimidazole
D004403	Dysentery	Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.	Infectious Diarrheal Disease,Diarrheal Disease, Infectious,Infectious Diarrheal Diseases
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013553	Swine Diseases	Diseases of domestic swine and of the wild boar of the genus Sus.	Disease, Swine,Diseases, Swine,Swine Disease
D014867	Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Hydrogen Oxide