-transparent.png){kind=logo}
Vanadium has recently been reported to induce interphase and M-phase (mitotic) programmed cell death via the generation of hydroxyl free radicals (OH*). In this paper, the effects of antioxidants on: (a) vanadyl[IV]-generated OH* free radical levels; and (b) cellular glutathione in vanadyl [IV]-treated Chang liver cells were evaluated. The surface morphology of vanadyl-treated mitotic cells was studied by confocal and scanning microscopy. The free radical scavengers zinc chloride, glucose and thiourea reduced the levels of vanadyl-induced OH* free radicals and partially prevented the depletion of cellular glutathione. Concurrent with OH* free radical production, vanadyl-treated telophase cells exhibited excessive cell blebbing and cell shrinkage. The morphological features demonstrated in vanadyl-induced mitotic programmed cell death as a consequence of oxidative stress is novel.
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
December 1992,
Biochemical and biophysical research communications,
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
February 2002,
Tissue & cell,
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
April 1997,
Cell death and differentiation,
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
January 2011,
International journal of molecular sciences,
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
November 2011,
Environmental science & technology,
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
April 2010,
Geochemical transactions,
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
February 2002,
Bioorganic & medicinal chemistry letters,
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
March 2009,
Ultrasonics sonochemistry,
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
March 2000,
Phytochemistry,
B H Bay, and
K H Sit, and
R Paramanantham, and
Y G Chan
January 1993,
Free radical research communications,
