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The aim of our study was to characterize functionally prejunctional neuropeptide Y (NPY) receptors in human and rabbit renal cortex, as well as in human right atrium. Segments of human atrial appendages and of human and rabbit renal cortex were preincubated with [3H]noradrenaline, superfused with Krebs-Henseleit solution and stimulated electrically in superfusion chambers. The stimulation-induced outflow of radioactivity was taken as an index of endogenous noradrenaline release. The effects of subtype-selective NPY analogs on the stimulation-induced noradrenaline release were studied. NPY, its endogenous analog, peptide YY, and its C-terminal fragment, NPY13-36, but not its analog, [Leu31,Pro34]NPY, concentration dependently (1-100 nM) inhibited [3H]noradrenaline release in all tissues studied. NPY-induced inhibition of [3H]noradrenaline release in human and rabbit kidney was abolished by pretreatment with pertussis toxin. We conclude that prejunctional inhibition of noradrenaline release in human heart and human and rabbit kidney occurs through NPY receptors of the Y2 subtype, which appear to couple to a pertussis toxin-sensitive G protein.
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
May 2004,
Naunyn-Schmiedeberg's archives of pharmacology,
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
May 2002,
Peptides,
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
January 1987,
Journal of cardiovascular pharmacology,
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
October 1995,
Biochemical and biophysical research communications,
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
August 1994,
European journal of pharmacology,
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
July 1991,
Brain research,
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
October 1990,
The Journal of biological chemistry,
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
March 2000,
Canadian journal of physiology and pharmacology,
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
March 2002,
European journal of pharmacology,
L C Rump, and
M Riess, and
E Schwertfeger, and
M C Michel, and
C Bohmann, and
P Schollmeyer
October 2011,
Clinical and translational science,
