BIOMAT Database Logo BIOMAT Database Logo

Clastogenicity and mutagenicity of hexavalent chromium in lacZ transgenic mice. 1997

S Itoh, and H Shimada
Drug Safety Research Laboratory, Daiichi Pharmaceutical Company Limited, Edogawa-ku, Tokyo, Japan.

The clastogenic and mutagenic effects of the hexavalent chromium compound K2CrO4 in lacZ transgenic mice (Muta Mouse) were investigated. Male Muta mice were administered an intraperitoneal dose of 40 mg/kg of K2CrO4 once on each of 2 consecutive days. The K2CrO4 induced a significant increase in the peripheral blood micronucleated reticulocyte count. Also, K2CrO4 induced a statistically significant increase in mutant frequency in the liver but not in the bone marrow on day 7 after the second treatment. The reason for the failure to increase the mutant frequency in the bone marrow may have been the rapid cell turnover rate there. The mutation induced by K2CrO4 in the bone marrow may have occurred in more differentiated cells than stem cells, and the rapid proliferative activity may have caused a rapid decrease in mutated cells by day 7. Further study with a sampling point earlier than day 7 is needed. The results obtained in the present study indicate that K2CrO4 has clastogenic and mutagenic potential in vivo.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008822 Mice, Transgenic Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. Transgenic Mice,Founder Mice, Transgenic,Mouse, Founder, Transgenic,Mouse, Transgenic,Mice, Transgenic Founder,Transgenic Founder Mice,Transgenic Mouse
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D001853 Bone Marrow The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D002274 Carcinogens, Environmental Carcinogenic substances that are found in the environment. Environmental Carcinogens
D002840 Chromates Salts of chromic acid containing the CrO(2-)4 radical. Chromate
D002857 Chromium A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality

Related Publications

S Itoh, and H Shimada
Mutagenicity of ethyl carbamate to lacZ- transgenic mice.
March 1998, Mutagenesis,
S Itoh, and H Shimada
Metabolic deactivation of hexavalent chromium mutagenicity.
October 1978, Mutation research,
S Itoh, and H Shimada
Toxicity and mutagenicity of hexavalent chromium on Salmonella typhimurium.
April 1977, Applied and environmental microbiology,
S Itoh, and H Shimada
The mutagenicity of hexavalent chromium is decreased by microsomal metabolism.
April 1978, Die Naturwissenschaften,
S Itoh, and H Shimada
Antioxidant activity, mutagenicity/anti-mutagenicity, and clastogenicity/anti-clastogenicity of lutein from marigold flowers.
September 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
S Itoh, and H Shimada
In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice.
September 1996, Mutation research,
S Itoh, and H Shimada
Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (MutaMouse).
March 2002, Mutation research,
S Itoh, and H Shimada
In vivo optical imaging of LacZ expression using lacZ transgenic mice.
August 2009, Assay and drug development technologies,
S Itoh, and H Shimada
Mutagenicity and clastogenicity of N-chloropiperidine.
January 1985, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
S Itoh, and H Shimada
Chromium and hexavalent chromium.
January 1993, Journal of applied toxicology : JAT,
Copied contents to your clipboard!