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After experimental retinal detachment in rabbits macrophages are a prominent feature in the subretinal space or within the retina. Two sources for these macrophages are identified. The retinal pigment epithelium (RPE) may undergo metaplasia and actively 'bud'; the evolving macrophage is then formed by a vitreal protrusion of the cytoplasm of an RPE cell which is 'nipped off' by lateral protrusions from adjacent cells. In addition, in regions of RPE proliferation, blood-borne cells were found in Bruch's membrane and among the mass of proliferated RPE cells, suggesting that blood-borne cells may pass from the choroidal circulation through Bruch's membrane and the RPE layer.
N F Johnson, and
W S Foulds
July 1972,
Nippon Ganka Gakkai zasshi,
N F Johnson, and
W S Foulds
June 1971,
Nihon ganka kiyo,
N F Johnson, and
W S Foulds
January 1971,
Nippon Ganka Gakkai zasshi,
N F Johnson, and
W S Foulds
March 2007,
Investigative ophthalmology & visual science,
N F Johnson, and
W S Foulds
August 2007,
American journal of ophthalmology,
N F Johnson, and
W S Foulds
January 1966,
Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology,
N F Johnson, and
W S Foulds
September 1985,
American journal of ophthalmology,
N F Johnson, and
W S Foulds
March 2019,
Scientific reports,
N F Johnson, and
W S Foulds
April 1986,
Archives of ophthalmology (Chicago, Ill. : 1960),
N F Johnson, and
W S Foulds
June 1968,
Archives of ophthalmology (Chicago, Ill. : 1960),
