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Chromatin core particles, containing 140 base pairs (bp) of DNA plus the inner histones, can be nearly quantitatively formed either by reassociation from 2 M NaCl or by reconstitution from salt extracted histones and DNA. The reassociated or reconstituted particles appear to be identical with the native particles in all physical properties examined (sedimentation velocity, histone content, circular dichroism, and melting) as well as in their patterns of digestion by micrococcal nuclease, DNase I, and trypsin. In the presence of excess DNA, no "half-particles" are formed. In the presence of excess histone, aggregated structures are formed in addition to 11S core particles.
K Tatchell, and
K E Van Holde
July 1982,
Journal of molecular biology,
K Tatchell, and
K E Van Holde
August 1983,
Biochimica et biophysica acta,
K Tatchell, and
K E Van Holde
September 1977,
Nature,
K Tatchell, and
K E Van Holde
March 1984,
Biochimica et biophysica acta,
K Tatchell, and
K E Van Holde
January 1978,
Cold Spring Harbor symposia on quantitative biology,
K Tatchell, and
K E Van Holde
May 1982,
Biokhimiia (Moscow, Russia),
K Tatchell, and
K E Van Holde
December 1982,
European journal of biochemistry,
K Tatchell, and
K E Van Holde
June 1978,
Nature,
K Tatchell, and
K E Van Holde
January 2004,
Methods in enzymology,
K Tatchell, and
K E Van Holde
January 1981,
Doklady Akademii nauk SSSR,
