Biomaterial Database

Pathogenesis of Salmonella enteritidis phage type four after experimental infection of young chickens. 1997

M Desmidt, and R Ducatelle, and F Haesebrouck

Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, University of Gent, Merelbeke, Belgium.

White leghorn specific-pathogen-free chickens were inoculated orally with Salmonella enteritidis phage type 4 at the age of one day (group 1) and four weeks (group 2). From 3 h until 4 weeks post inoculation (pi), birds were sacrificed. Gross lesions were recorded and different sites of the intestine and visceral organs were collected for bacteriological and histopathological examination. Clinical disease and mortality were only observed in group 1. Mortality was 8%. The birds were depressed, had diarrhoea and an indurated yolk sac. Infection of the liver and the heart was present within 12 h pi in both groups. The percentage of infected organs was very high and similar in both groups during the first week pi. Thereafter the isolation rate of Salmonella was declining faster in group 2. The crop, the proventriculus, the lower intestinal tract and the bursa of Fabricius were the predilective sites of isolation in both groups. Most prevalent lesions were serous typhlitis, omphalitis and polyserositis. Histopathology revealed inflammation in the intestines and visceral organs. In some birds granulomatous nodules were present in the caeca. Antibodies were detected from 18 and 5 days pi in group 1 and 2, respectively. Granulomatous nodules were typical of infection with this strain of S. enteritidis phage type 4. These granulomatous nodules together with the retained yolk sac possibly are a source of Salmonella organisms that may account for intermittent faecal shedding by carrier birds.

UI	MeSH Term	Description	Entries
D011201	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	Disease, Poultry,Diseases, Poultry,Poultry Disease
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000907	Antibodies, Bacterial	Immunoglobulins produced in a response to BACTERIAL ANTIGENS.	Bacterial Antibodies
D001434	Bacteriophage Typing	A technique of bacterial typing which differentiates between bacteria or strains of bacteria by their susceptibility to one or more bacteriophages.	Phage Typing,Typing, Bacteriophage,Typing, Phage
D012477	Salmonella enteritidis	A serotype of Salmonella enterica which is an etiologic agent of gastroenteritis in man and other animals.	Salmonella enterica serovar enteritidis
D012481	Salmonella Infections, Animal	Infections in animals with bacteria of the genus SALMONELLA.	Animal Salmonella Infection,Animal Salmonella Infections,Infection, Animal Salmonella,Infections, Animal Salmonella,Salmonella Infection, Animal
D017122	Bacteriophage T4	Virulent bacteriophage and type species of the genus T4-like phages, in the family MYOVIRIDAE. It infects E. coli and is the best known of the T-even phages. Its virion contains linear double-stranded DNA, terminally redundant and circularly permuted.	Bacteriophage T2,Coliphage T2,Coliphage T4,Enterobacteria phage T2,Enterobacteria phage T4,Phage T2,Phage T4,T2 Phage,T4 Phage,Phage, T2,Phage, T4,Phages, T2,Phages, T4,T2 Phages,T2, Enterobacteria phage,T4 Phages