-transparent.png){kind=logo}
Kynurenine 3-monooxygenase, an NADPH-dependent flavin monooxygenase, catalyses the hydroxylation of L-kynurenine to L-3-hydroxykynurenine. By hybridization screening using a cDNA probe encoding the entire exon 2 of Drosophila melanogaster kynurenine 3-monooxygenase, we isolated a 2.0 kb cDNA clone coding for the corresponding human liver enzyme. The deduced amino acid sequence of the human protein consists of 486 amino acids with a predicted molecular mass of 55,762 Da. Transfection of the human cDNA in HEK-293 cells resulted in the functional expression of the enzyme with kinetic properties similar to those found for the native human protein. RNA blot analysis of human tissues revealed the presence of a major mRNA species of approximately 2.0 kb in liver, placenta and kidney.
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
March 2014,
Protein expression and purification,
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
August 2021,
Cells,
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
January 2022,
Molecules (Basel, Switzerland),
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
January 2021,
Frontiers in oncology,
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
October 2002,
Insect molecular biology,
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
April 2013,
Nature,
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
February 2007,
Protein expression and purification,
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
January 2015,
Frontiers in psychiatry,
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
January 2000,
Redox report : communications in free radical research,
D Alberati-Giani, and
A M Cesura, and
C Broger, and
W D Warren, and
S Röver, and
P Malherbe
June 2014,
Genetika,
