Biomaterial Database

Plasma and saliva concentrations of rifampicin in man after oral administration. 1996

O E Orisakwe, and S I Ofoefule

Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnew, Nigeria.

The saliva and plasma concentrations of rifampicin were determined following oral administration of 600 mg of the drug to healthy human subjects. Rifampicin is a zwitterion with PKa's of 1.7 and 7.9. The saliva-plasma concentration ratios calculated on the basis of the PKa of 1.7 was 1.6346. The saliva concentrations were much higher than the MICs of a variety of organisms, indicating the possible usefulness of rifampicin in the treatment of susceptible oropharyngeal and nasopharyngeal pathogens. After 24 hrs, when rifampicin was completely absent in the urine, the saliva and plasma concentrations also had fallen almost to zero.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012293	Rifampin	A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	Rifampicin,Benemycin,Rifadin,Rimactan,Rimactane,Tubocin
D012463	Saliva	The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.	Salivas