-transparent.png){kind=logo}
We report in this study a patient who developed repeated convulsions as a result of valproate therapy. MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) was subsequently diagnosed and a nucleotide 3243 A-->G mutation was detected in the mitochondrial DNA. This mutation predisposes the patient to the detrimental effects of valproate on oxidative phosphorylation. CONCLUSIONS We support the suggestion of Ponchaut et al. [14] that valproate should not be given to patients suspected of having mitochondrial diseases. In addition, for patients whose seizures worsen with valproate therapy, an inborn error of mitochondrial metabolism should be suspected. The underlying mitochondrial DNA defects should be sought for family screening and genetic counselling.
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
January 2001,
Ryoikibetsu shokogun shirizu,
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
March 2021,
No shinkei geka. Neurological surgery,
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
May 2013,
Journal of pediatric neurosciences,
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
January 1997,
Clinical neuropathology,
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
January 1991,
Biochemical and biophysical research communications,
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
February 1985,
Rinsho shinkeigaku = Clinical neurology,
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
February 2016,
Brain and nerve = Shinkei kenkyu no shinpo,
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
November 2010,
Pharmacotherapy,
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
March 2019,
Mitochondrion,
C W Lam, and
C H Lau, and
J C Williams, and
Y W Chan, and
L J Wong
September 1993,
Nihon rinsho. Japanese journal of clinical medicine,
