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In six experiments the course of a Trichinella spiralis infection in congenitally athymic (nu/nu) mice and their heterozygous thymus-bearing littermates (+/nu) was followed. In the +/nu mice worms were expelled at day 10 post infection. In nu/nu mice worms remained in the intestine until the end of the observation period (83 days post infection). In testing the yield of muscle larvae in +/nu and nu/nu mice 4--5 times more muscle larvae were isolated from nu/nu mice than from infected +/nu mice. The following phenomena were observed in +/nu mice only: anti-T. spiralis antibodies detected by immunofluorescence, intestinal plasma-cell production and intestinal eosinophilia. In nu/nu mice no blood eosinophilia was observed in contrast to the induction of eosinophilia both in infected +/nu and infected nu/nu mice reconstituted with thymuses from heterozygous littermates. Intra-epithelial lymphocytes, more numerous in +/nu than in nu/nu mice, were not attracted by Trichinella antigen. The data supported the hypothesis that worm expulsion is a T cell-dependent phenomenon. Plasma cell and antibody production as well as tissue and blood eosinophilia were shown to be thymus-dependent in a T. spiralis infection.
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
December 1974,
The Journal of parasitology,
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
January 1980,
Zeitschrift fur Parasitenkunde (Berlin, Germany),
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
February 1976,
Journal of the Reticuloendothelial Society,
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
March 1984,
Infection and immunity,
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
June 1978,
Infection and immunity,
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
January 1976,
Annales de microbiologie,
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
May 1977,
Infection and immunity,
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
June 1985,
Infection and immunity,
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
October 1978,
Infection and immunity,
E J Ruitenberg, and
A Elgersma, and
W Kruizinga, and
F Leenstra
January 1975,
Birth defects original article series,
