-transparent.png){kind=logo}
A 79-year-old male was admitted to our hospital because of general fatigue and night sweat. Physical examination showed generalized superficial lymphadenopathy, marked splenomegaly, and tumors in the conjunctiva and the abdomen. Chest X-ray and computed tomography (CT) revealed pleural effusion and intrathoracic lymphadenopathy. Abdominal ultrasonography and CT showed hepatosplenomegaly and intraperitoneal tumors. Upper gastrointestinal fiberscopy revealed multiple polypoid lesions and ulcers in the duodenum and the stomach. Involvement of relatively small-sized lymphocytes with cleaved nuclei was identified in each biopsied specimen from a cervical lymph node, a tumor in the conjunctiva, gastrointestinal polypoid lesions, and the bone marrow. Surface marker analysis of abnormal lymphocytes in the bone marrow revealed that CD5, CD19, and CD20 were strongly positive, but CD23 was weakly positive. Although (11:14)(q13:q32) translocation was not identified by chromosome analysis of bone marrow cells, Northern blot analysis of bone marrow cells revealed overexpression of the PRAD1 oncogene. Diagnosis of mantle cell lymphoma (MCL) was made. Combination chemotherapy by cyclophosphamide and vincristine was not effective, but etoposide perorally given at a dose of 50 mg per day was effective. In MCL, extranodal involvement of a digestive tract and bone marrow is well known. This case suggests that involvement of multiple organs including lacrimal glands and pleura could be characteristic of MCL cells.
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
January 2015,
Endoscopy,
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
January 2005,
Terapevticheskii arkhiv,
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
December 2001,
Histopathology,
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
December 2007,
Histopathology,
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
January 2017,
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons,
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
February 2007,
Der Pathologe,
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
January 2008,
Radiology case reports,
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
March 2012,
Revista espanola de enfermedades digestivas,
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
June 2015,
Postepy dermatologii i alergologii,
K Orii, and
H Kobayashi, and
M Ueno, and
F Ishida, and
H Saito, and
S Hata, and
K Aoki, and
A Narita, and
S Shimodaira, and
K Kitano, and
K Uchimaru, and
T Motokura
October 2007,
Clinical advances in hematology & oncology : H&O,
