-transparent.png){kind=logo}
We report a patient who had generalized painful muscle cramps associated with isolated ACTH deficiency. A 68-year-old woman was hospitalized because of painful muscle cramps present for one year. Neurological examination revealed no abnormalities except for generalized painful muscle cramps. Serum electrolyte and CPK levels were normal. Serum ACTH and cortisol levels as well as urine 17-OHCS were low. An ACTH loading test employing insulin, TRH and LH-RH indicated isolated ACTH deficiency. Just after the muscle cramp, EMG revealed a low amplitude in the biceps muscle. Colon biopsy showed mild fibrosis and inflammatory cell infiltration in the lamina propria. Her muscle cramps improved markedly after two weeks of hydrocortisone replacement therapy and resolved after three weeks, suggesting that this symptom was closely related to isolated ACTH deficiency. Our case suggests that isolated ACTH deficiency may present with very similar clinical symptoms to Satoyoshi disease.
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
December 1983,
Acta endocrinologica,
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
April 1988,
Nederlands tijdschrift voor geneeskunde,
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
February 1988,
The American journal of the medical sciences,
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
October 1972,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
February 1994,
Rinsho shinkeigaku = Clinical neurology,
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
September 1998,
No to shinkei = Brain and nerve,
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
February 1974,
Nihon Naibunpi Gakkai zasshi,
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
May 2000,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
January 1980,
Journal of endocrinological investigation,
T Matsui, and
T Hatayama, and
K Okuda, and
M Kitaguchi, and
M Takahashi
January 1990,
Recenti progressi in medicina,
