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The metabolism of putrescine in neuroblastoma and glioma cells was analyzed during culture. In the former cells the formation of gamma-aminobutyric acid from putrescine was low and constant during the logarithmic phase and increased dramatically during the stationary phase or in cultures with low serum concentrations, while in the latter cells it was low and constant throughout culture. The formation of spermidine from putrescine in both cell lines was active at days 1-2 of culture and decreased gradually during culture. These findings indicate that spermidine formation is closely related to proliferation of the cells, and gamma-aminobutyric acid formation to differentiation or maturation of the neuroblastoma cells.
K Sobue, and
T Nakajima
November 1976,
Journal of neurochemistry,
K Sobue, and
T Nakajima
November 1981,
Proceedings of the National Academy of Sciences of the United States of America,
K Sobue, and
T Nakajima
January 1981,
Cellular and molecular biology, including cyto-enzymology,
K Sobue, and
T Nakajima
January 1985,
Methods in enzymology,
K Sobue, and
T Nakajima
May 1973,
The Journal of clinical endocrinology and metabolism,
K Sobue, and
T Nakajima
November 1982,
Biochemical and biophysical research communications,
K Sobue, and
T Nakajima
January 1975,
Journal of neurochemistry,
K Sobue, and
T Nakajima
January 1976,
Advances in prostaglandin and thromboxane research,
K Sobue, and
T Nakajima
April 1976,
The Journal of biological chemistry,
K Sobue, and
T Nakajima
January 1993,
Noshuyo byori = Brain tumor pathology,
