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The present study examined the impact of comorbid major depressive disorder (MDD) on psychiatric morbidity, panic symptomatology and frequency of other comorbid psychiatric conditions in subjects with panic disorder (PD). Four hundred thirty-seven patients with PD were evaluated at intake as part of a multicenter longitudinal study of anxiety disorders; 113 of these patients were also in an episode of MDD. Patients were diagnosed by DSM-III-R criteria utilizing structured clinical interviews. The 113 PD/MDD patients were compared with the 324 remaining PD subjects regarding panic symptoms at intake, sociodemographic, quality of life and psychiatric morbidity variables. Differences in frequency of other comorbid Axis I psychiatric disorders were assessed at intake; personality disorders were evaluated twelve months after intake. The results revealed the PD/MDD patients exhibit increased morbidity and decreased psychosocial functioning as compared to PD patients. Personality disorders were more prevalent in the PD/MDD group at six month follow-up assessment; the PD/MDD group also had an increased frequency of posttraumatic stress disorder (PTSD) and more comorbid Axis I anxiety disorders as compared to the PD group. The total number and frequency of panic symptoms was highly consistent between the two patient groups.
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
July 1984,
Archives of general psychiatry,
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
February 1994,
The American journal of psychiatry,
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
June 1998,
Psychiatry research,
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
May 1994,
Archives of general psychiatry,
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
April 1989,
Acta psychiatrica Scandinavica,
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
January 1989,
Journal of affective disorders,
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
December 1984,
Archives of general psychiatry,
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
August 1998,
Psychiatry and clinical neurosciences,
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
November 1994,
The Journal of clinical psychiatry,
R G Vasile, and
I Goldenberg, and
J Reich, and
R M Goisman, and
P W Lavori, and
M B Keller
May 1992,
Biological psychiatry,
