BIOMAT Database Logo BIOMAT Database Logo

Age-related changes in susceptibility of mice to low-virulent mouse hepatitis virus (MHV-2-CC) infection. 1997

H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.

This study was performed to examine mouse age-dependent changes in susceptibility to MHV-2-CC-infection and participation of macrophages in such changes in BALB/c mice. One-week-old mice were fully susceptible (mortality, 100%), 2-week-old semi-susceptible (36%), and 3- and 4-week-old fully resistant (0%) to MHV-2-CC, respectively. Such age-dependent differences corresponded well with the differences in the virus titers in the liver, spleen and blood and in the severity of liver lesions. In 1-week-old mice with peritoneal exudate cells (PEC) transferred from 4-week-old mice and infected with MHV-2-CC, a slight prolongation of survival time was recorded, although there was no difference in mortality. In 3-week-old mice infected with MHV-2-CC after silica-treatment to suppress macrophages, there was no significant change in susceptibility. In macrophages infected with MHV-2-CC in vitro, the virus replicated better in macrophages obtained from younger mice. These results suggest that macrophages may play a small role in the age-related development of resistance to MHV-2-CC infection in BALB/c mice.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008262 Macrophage Activation The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants. Activation, Macrophage,Activations, Macrophage,Macrophage Activations
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D004198 Disease Susceptibility A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases. Diathesis,Susceptibility, Disease,Diatheses,Disease Susceptibilities,Susceptibilities, Disease
D005260 Female Females
D006517 Murine hepatitis virus A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis). Gastroenteritis Virus, Murine,Hepatitis Virus, Mouse,Mouse Hepatitis Virus,Murine Gastroenteritis Virus,MHV-JHM,Murine coronavirus,Gastroenteritis Viruses, Murine,Hepatitis Viruses, Mouse,Mouse Hepatitis Viruses,Murine Gastroenteritis Viruses,Murine coronaviruses,Murine hepatitis viruses
D006524 Hepatitis, Viral, Animal INFLAMMATION of the LIVER in animals due to viral infection. Viral Hepatitis, Animal,Animal Viral Hepatitides,Animal Viral Hepatitis,Viral Hepatitides, Animal
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging

Related Publications

H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
Mouse hepatitis virus (MHV) infection in thymectomized C3H mice.
October 1978, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
Mouse Hepatitis Virus Receptor as a Determinant of the Mouse Susceptibility to MHV Infection.
January 2012, Frontiers in microbiology,
H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
Age-dependent response of mice to a mouse hepatitis virus, MHV-S.
April 1977, The Japanese journal of experimental medicine,
H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
Pathology of active hepatitis in athymic nude mice caused by a mutant strain of mouse hepatitis virus, MHV-2-CC.
December 1985, Nihon juigaku zasshi. The Japanese journal of veterinary science,
H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
Apoptotic changes in the thymus of mice infected with mouse hepatitis virus, MHV-2.
October 1994, The Journal of veterinary medical science,
H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
Histopathology and hematology of acute infection with mouse hepatitis virus, MHV-3 in mice with different susceptibility.
October 1985, Nihon juigaku zasshi. The Japanese journal of veterinary science,
H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
Modulation of resistance to Salmonella typhimurium infection in mice by mouse hepatitis virus (MHV).
February 1989, Microbial pathogenesis,
H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
A virus related to that causing hepatitis in mice (MHV).
February 1956, British journal of experimental pathology,
H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
T lymphocyte-dependent difference in susceptibility between DDD and C3H mice to mouse hepatitis virus, MHV-3.
December 1979, The Japanese journal of experimental medicine,
H Suzuki, and W Kiatipattanasakul, and S Kajikawa, and S Tsutsui, and H Nakayama, and N Goto, and K Doi
Susceptibility of cortisone-treated mice to infection with mouse hepatitis virus.
October 1958, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
Copied contents to your clipboard!