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Somatostatin was infused for 6 h into seven normal subjects with and without a replacement dose of glucagon. The addition of glucagon to somatostatin resulted in a 30-40% rise in plasma glucagon, whereas plasma insulin declined by 40-50% in both treatment groups. Plasma glucose and glucose production initially increased 2-fold with glucagon replacement, and subsequently declined by 2-3 h to levels comparable to those observed with somatostatin alone. After 6 h plasma glucose and glucose kinetics were no different whether or not glucagon was present. The rise in blood ketones after somatostatin was not exaggerated by glucagon replacement. We conclude that glucagon lack is not a modifying factor in the late hyperglycemic and hyperketonemic response to prolonged infusions of somatostatin.
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
October 1983,
Diabetes,
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
March 1984,
The Journal of clinical endocrinology and metabolism,
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
September 1984,
Clinical endocrinology,
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
October 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
January 1954,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
January 1986,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
January 1990,
Acta diabetologica latina,
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
September 1979,
The Journal of pharmacology and experimental therapeutics,
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
October 1978,
Diabetes,
R S Sherwin, and
W Tamborlane, and
R Hendler, and
L Saccá, and
R A DeFronzo, and
P Felig
August 1977,
Diabetologia,
