BIOMAT Database Logo BIOMAT Database Logo

Estrogen or testosterone increases self-reported aggressive behaviors in hypogonadal adolescents. 1997

J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey 16802, USA. jwf3@psu.edu

A randomized, double-blinded, placebo-controlled cross-over clinical trial was used to determine the role of sex steroids on the development of aggressive behaviors in 35 boys and 14 girls. Depo-testosterone (to boys) or conjugated estrogens (to girls) was administered in 3-month blocks alternating with placebo at three dose levels approximating early, middle and late pubertal amounts. The Olweus Multifaceted Aggression Inventory was administered after each placebo and treatment period to ascertain the effect of sex steroids on self-reported aggressive behaviors. We employed a strict intent-to-treat analytical model. The data demonstrated significant hormone effects on physical aggressive behaviors and aggressive impulses, but not in verbal aggressive behaviors nor aggressive inhibitions in both boys and girls. These results are the first to causally relate the administration of physiological doses of sex steroids to changes in aggressive behaviors in adolescents.

UI MeSH Term Description Entries
D007006 Hypogonadism Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism). Hypergonadotropic Hypogonadism,Hypogonadism, Isolated Hypogonadotropic,Hypogonadotropic Hypogonadism,Hypogonadism, Hypergonadotropic,Hypogonadism, Hypogonadotropic
D007986 Luteinizing Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity. ICSH (Interstitial Cell Stimulating Hormone),Interstitial Cell-Stimulating Hormone,LH (Luteinizing Hormone),Lutropin,Luteoziman,Luteozyman,Hormone, Interstitial Cell-Stimulating,Hormone, Luteinizing,Interstitial Cell Stimulating Hormone
D008297 Male Males
D010919 Placebos Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol. Sham Treatment
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004966 Estrogens, Conjugated (USP) A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate. Conjugated Equine Estrogen,Conjugated Estrogen,Estrogenic Substances, Conjugated,Progen,Carentil,Climarest,Climopax,Congest,Conjugated Equine Estrogens,Conjugated Estrogens,Dagynil,Estro-Feminal,Estrogenic Hormones, Conjugated,Estrogens, Conjugated,Femavit,Oestro-Feminal,Oestrofeminal,Prelestrin,Premarin,Presomen,Progens,Transannon,Conjugated Estrogenic Hormones,Conjugated Estrogenic Substances,Equine Estrogen, Conjugated,Equine Estrogens, Conjugated,Estro Feminal,Estrogen, Conjugated,Estrogen, Conjugated Equine,Oestro Feminal
D004970 Estrone An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women. Folliculin (Hormone),Estrone, (+-)-Isomer,Estrone, (8 alpha)-Isomer,Estrone, (9 beta)-Isomer,Estrovarin,Kestrone,Unigen,Wehgen
D005260 Female Females
D005640 Follicle Stimulating Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity. FSH (Follicle Stimulating Hormone),Follicle-Stimulating Hormone,Follitropin

Related Publications

J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Rosiglitazone increases testosterone in hypogonadal type 2 diabetic men.
January 2009, Diabetes & vascular disease research,
J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Clomiphene Citrate Effectively Increases Testosterone in Obese, Young, Hypogonadal Men.
December 2015, Reproductive system & sexual disorders : current research,
J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Self-reported alcohol use and sexual behaviors of adolescents.
February 2003, Psychological reports,
J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Reported sexual behaviors and self-esteem among young adolescents.
January 1989, American journal of diseases of children (1960),
J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Relationship between levels of testosterone and cortisol in saliva and aggressive behaviors of adolescents.
February 2009, Biomedical and environmental sciences : BES,
J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Self-reported depression and risk-taking behaviors among Hispanic adolescents.
August 1997, Psychological reports,
J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Testosterone and Estrogen Repletion in a Hypogonadal Environment Improves Post-operative Angiogenesis.
June 2021, Urology,
J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Testosterone replacement increases fat-free mass and muscle size in hypogonadal men.
January 1997, JPEN. Journal of parenteral and enteral nutrition,
J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Testosterone replacement increases fat-free mass and muscle size in hypogonadal men.
February 1997, The Journal of clinical endocrinology and metabolism,
J W Finkelstein, and E J Susman, and V M Chinchilli, and S J Kunselman, and M R D'Arcangelo, and J Schwab, and L M Demers, and L S Liben, and G Lookingbill, and H E Kulin
Modification of hostile attribution bias reduces self-reported reactive aggressive behavior in adolescents.
June 2020, Journal of experimental child psychology,
Copied contents to your clipboard!