BIOMAT Database Logo BIOMAT Database Logo

Angiotensin II induces media hypertrophy and hyperreactivity in mesenteric but not epigastric small arteries of the rat. 1997

F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Department of Pharmacology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands.

We examined effects of a 2-week infusion of angiotensin II (AII, 250 ng x kg[-1] x min[-1]) on properties of mesenteric resistance arteries (MrA) and superior epigastric arteries (SEA) of male Wistar rats. Histochemistry and pharmacological tools showed that MrA are densely innervated, whereas SEA are only sparsely innervated. AII infusion resulted in a significant elevation in mean arterial pressure and in plasma AII and noradrenaline levels. Organ chamber studies and morphometry were used to determine arterial contractile reactivity and structure. After AII infusion, in MrA (i) maximal contractile responses to 125 mM K+, noradrenaline, serotonin and adrenergic nerve stimulation were significantly increased, without modification of the sensitivity to these stimuli and (ii) a significant increase in media cross-sectional area and media thickness was observed without alterations in lumen diameter. The observed increase in vascular reactivity could fully be attributed to the observed increase in wall mass since no alterations in maximal active wall stress were noted. In SEA, no significant changes in responsiveness to vasoconstrictor stimuli or in wall structure were observed. These findings suggest that perivascular nerves are involved in the hypertrophy and subsequent hyperreactivity of small arteries in rats exposed for 2 weeks to a low dose of AII.

UI MeSH Term Description Entries
D006984 Hypertrophy General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA). Hypertrophies
D008297 Male Males
D008638 Mesenteric Arteries Arteries which arise from the abdominal aorta and distribute to most of the intestines. Arteries, Mesenteric,Artery, Mesenteric,Mesenteric Artery
D009478 Neuropeptide Y A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones. Neuropeptide Y-Like Immunoreactive Peptide,Neuropeptide Tyrosine,Neuropeptide Y Like Immunoreactive Peptide,Tyrosine, Neuropeptide
D002211 Capsaicin An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS. 8-Methyl-N-Vanillyl-6-Nonenamide,Antiphlogistine Rub A-535 Capsaicin,Axsain,Capsaicine,Capsicum Farmaya,Capsidol,Capsin,Capzasin,Gelcen,Katrum,NGX-4010,Zacin,Zostrix,8 Methyl N Vanillyl 6 Nonenamide,NGX 4010,NGX4010
D000804 Angiotensin II An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS. Angiotensin II, Ile(5)-,Angiotensin II, Val(5)-,5-L-Isoleucine Angiotensin II,ANG-(1-8)Octapeptide,Angiotensin II, Isoleucine(5)-,Angiotensin II, Valine(5)-,Angiotensin-(1-8) Octapeptide,Isoleucine(5)-Angiotensin,Isoleucyl(5)-Angiotensin II,Valyl(5)-Angiotensin II,5 L Isoleucine Angiotensin II,Angiotensin II, 5-L-Isoleucine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014661 Vasoconstriction The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE. Vasoconstrictions
D015740 Calcitonin Gene-Related Peptide A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator. Calcitonin Gene-Related Peptide I,Calcitonin Gene-Related Peptide II,alpha-CGRP,alpha-Calcitonin Gene-Related Peptide,beta-CGRP,beta-Calcitonin Gene-Related Peptide,Calcitonin Gene Related Peptide,Calcitonin Gene Related Peptide I,Calcitonin Gene Related Peptide II,Gene-Related Peptide, Calcitonin,alpha Calcitonin Gene Related Peptide,beta Calcitonin Gene Related Peptide

Related Publications

F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Diabetes induces Na/H exchange activity and hypertrophy of rat mesenteric but not basilar arteries.
December 2005, Diabetes research and clinical practice,
F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Nebivolol induces NO-mediated relaxations of rat small mesenteric but not of large elastic arteries.
September 2000, Journal of cardiovascular pharmacology,
F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Superoxide Dismutase Activity in Small Mesenteric Arteries Is Downregulated by Angiotensin II but Not by Hypertension.
October 2018, Toxicological research,
F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Cromakalim and pinacidil dilate small mesenteric arteries but not small cerebral arteries.
August 1991, The American journal of physiology,
F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.
April 1988, Circulation research,
F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries.
September 2011, Cardiovascular research,
F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Role of endothelial nitric oxide in the response to angiotensin II of small mesenteric arteries of the rat.
January 1996, Journal of vascular research,
F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Activated angiotensin II generation and regulation in rat mesenteric arteries following nephrectomy.
January 1994, Blood pressure. Supplement,
F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart.
February 2009, European journal of pharmacology,
F R Stassen, and N J Raat, and D L Brouwers-Ceiler, and G E Fazzi, and J F Smits, and J G De Mey
Reduced expression of SKCa and IKCa channel proteins in rat small mesenteric arteries during angiotensin II-induced hypertension.
May 2007, American journal of physiology. Heart and circulatory physiology,
Copied contents to your clipboard!