BIOMAT Database Logo BIOMAT Database Logo

Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation. 1997

N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Department of Pediatric Oncology, Dana Farber Cancer Institute, and Children's Hospital, Boston, MA 02115, USA.

Severe aplastic anemia (SAA) is a frequent complication of orthotopic liver transplantation for non-typeable viral hepatitis. Allogeneic bone marrow transplantation (BMT) may successfully reconstitute hematopoiesis but the optimal conditioning regimen and graft-versus-host disease (GVHD) prophylaxis in such patients are unknown. Allogeneic BMT was undertaken in an 8-year-old male patient who developed SAA 6 weeks after cadaveric orthotopic liver transplantation for fulminant hepatic failure secondary to presumed non-typeable viral hepatitis. The preparative regimen for his HLA genotypically identical sibling BMT consisted of cytoxan and anti-thymocyte globulin. Tacrolimus (FK506) and prednisone, used to prevent liver graft rejection, were supplemented with methotrexate on post-BMT days, 1, 3, 6 and 11 for GVHD prophylaxis. Engraftment proceeded promptly and without complications. Transfusion dependence resolved 6 weeks after BMT. The patient is alive and well 1 year after his BMT on FK506 and prednisone without any signs of GVHD or liver allograft rejection. This case is the first demonstration of the feasibility of continuing FK506 used for prevention of liver graft rejection as GVHD prophylaxis for allogeneic BMT.

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D006084 Graft Rejection An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. Transplant Rejection,Rejection, Transplant,Transplantation Rejection,Graft Rejections,Rejection, Graft,Rejection, Transplantation,Rejections, Graft,Rejections, Transplant,Rejections, Transplantation,Transplant Rejections,Transplantation Rejections
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000741 Anemia, Aplastic A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. Anemia, Hypoplastic,Aplastic Anaemia,Aplastic Anemia,Anaemia, Aplastic,Aplastic Anaemias,Aplastic Anemias,Hypoplastic Anemia,Hypoplastic Anemias
D014184 Transplantation, Homologous Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals. Transplantation, Allogeneic,Allogeneic Grafting,Allogeneic Transplantation,Allografting,Homografting,Homologous Transplantation,Grafting, Allogeneic
D016026 Bone Marrow Transplantation The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION. Bone Marrow Cell Transplantation,Grafting, Bone Marrow,Transplantation, Bone Marrow,Transplantation, Bone Marrow Cell,Bone Marrow Grafting
D016031 Liver Transplantation The transference of a part of or an entire liver from one human or animal to another. Grafting, Liver,Hepatic Transplantation,Liver Transplant,Transplantation, Hepatic,Transplantation, Liver,Hepatic Transplantations,Liver Grafting,Liver Transplantations,Liver Transplants,Transplant, Liver
D016559 Tacrolimus A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Anhydrous Tacrolimus,FK-506,FK506,FR-900506,Prograf,Prograft,Tacrolimus Anhydrous,Anhydrous, Tacrolimus,FK 506,FR 900506,FR900506,Tacrolimus, Anhydrous

Related Publications

N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Allogeneic bone marrow transplantation for severe aplastic anemia.
October 1991, Seminars in hematology,
N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Successful bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation: long-term follow-up and outcome.
September 2001, Bone marrow transplantation,
N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
[Allogeneic bone marrow transplantation for aplastic anemia].
September 1990, Nihon rinsho. Japanese journal of clinical medicine,
N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Allogeneic bone marrow transplantation for aplastic anemia.
March 2024, International journal of hematology,
N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Immunotherapy for severe aplastic anemia following orthotopic liver transplantation in children.
July 2007, Pediatric blood & cancer,
N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Allogeneic bone marrow transplantation for severe aplastic anemia: the Vancouver experience.
April 1995, Clinical and investigative medicine. Medecine clinique et experimentale,
N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Severe autoimmune thrombocytopenia after allogeneic bone marrow transplantation for aplastic anemia.
August 2001, International journal of hematology,
N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Allogeneic bone marrow transplantation for 144 patients with severe aplastic anemia.
March 1981, JAMA,
N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Allogeneic bone marrow transplantation for fourteen patients with severe aplastic anemia.
April 1996, Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
N S Trede, and A B Warwick, and P M Rosoff, and R Rohrer, and B E Bierer, and E Guinan
Allogeneic bone marrow transplantation in 25 patients with severe aplastic anemia.
July 1988, Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
Copied contents to your clipboard!