BIOMAT Database Logo BIOMAT Database Logo

General class of multiparticulate dissolution models. 1977

P V Pedersen, and K F Brown

The dissolution of multiparticulate systems under sink and nonsink conditions can be described rigorously according to a generally applicable formula on the basis of the single-particle dissolution model and the initial particle distribution. The kinetic model for log-normal systems dissolving under sink conditions is extended to nonsink conditions as a specific example. The equation presented describes a general class of multiparticulate models for various values of the dispersion parameter and the dissolution capacity coefficient.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008956 Models, Chemical Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment. Chemical Models,Chemical Model,Model, Chemical
D011208 Powders Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed) Powder
D012995 Solubility The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Solubilities

Related Publications

P V Pedersen, and K F Brown
Particle size distributions from multiparticulate dissolution.
July 1998, Drug development and industrial pharmacy,
P V Pedersen, and K F Brown
Dissolution rate studies. 3. Penetration model for describing dissolution of a multiparticulate system.
April 1965, Journal of pharmaceutical sciences,
P V Pedersen, and K F Brown
Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms.
September 2013, AAPS PharmSciTech,
P V Pedersen, and K F Brown
Muon capture in a general class of weak models.
October 1985, Physical review. D, Particles and fields,
P V Pedersen, and K F Brown
Microbeads: a novel multiparticulate drug delivery technology for increasing the solubility and dissolution of celecoxib.
March 2015, Pharmaceutical development and technology,
P V Pedersen, and K F Brown
Assessment of dynamic image analysis as a surrogate dissolution test for a coated multiparticulate product.
January 2006, Pharmaceutical development and technology,
P V Pedersen, and K F Brown
Estimating unconscious processes: implications of a general class of models.
June 1996, Journal of experimental psychology. General,
P V Pedersen, and K F Brown
Item Response Thresholds Models: A General Class of Models for Varying Types of Items.
December 2022, Psychometrika,
P V Pedersen, and K F Brown
Semiparametric Inference for a General Class of Models for Recurrent Events.
June 2007, Journal of statistical planning and inference,
P V Pedersen, and K F Brown
Critical properties of a general class of Z(5)-symmetric spin models.
November 1990, Physical review. B, Condensed matter,
Copied contents to your clipboard!