Dissolution kinetics of soluble nondisintegrating disks. 1977

C J de Blaey, and H van der Graaff

An equation describing the isotropical dissolution of soluble nondisintegrating disks was developed. It was equivalent to the cube root law only if the height and diameter of the disk were equal. The dissolution kinetics of sodium chloride disks were examined, using a beaker equipped with a centrifugal stirrer as the dissolution chamber. The fit of the experimental data to the cube root law had a coefficient of variation of about 4-5%. It was demonstrated statistically that a fit to a square root of mass versus time relation was significantly better. With increasing porosity, the dissolution process proceeded faster than predicted on the basis of the diffusion-convection model. An explanation is proposed by assuming an increased effective dissolution surface.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008956 Models, Chemical Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment. Chemical Models,Chemical Model,Model, Chemical
D003720 Densitometry The measurement of the density of a material by measuring the amount of light or radiation passing through (or absorbed by) the material. Densitometries
D012965 Sodium Chloride A ubiquitous sodium salt that is commonly used to season food. Sodium Chloride, (22)Na,Sodium Chloride, (24)NaCl
D012995 Solubility The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Solubilities
D013499 Surface Properties Characteristics or attributes of the outer boundaries of objects, including molecules. Properties, Surface,Property, Surface,Surface Property
D013607 Tablets Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed) Tablet

Related Publications

C J de Blaey, and H van der Graaff
December 1981, Journal of pharmaceutical sciences,
C J de Blaey, and H van der Graaff
March 1991, Chemical & pharmaceutical bulletin,
C J de Blaey, and H van der Graaff
February 1976, Journal of pharmaceutical sciences,
C J de Blaey, and H van der Graaff
January 1976, Journal of pharmaceutical sciences,
C J de Blaey, and H van der Graaff
December 1981, Journal of pharmaceutical sciences,
C J de Blaey, and H van der Graaff
October 1966, Nature,
C J de Blaey, and H van der Graaff
August 2013, Chemphyschem : a European journal of chemical physics and physical chemistry,
C J de Blaey, and H van der Graaff
December 2006, Acta pharmaceutica (Zagreb, Croatia),
Copied contents to your clipboard!