BIOMAT Database Logo BIOMAT Database Logo

Chromosome aberrations after radiotherapy in patients treated for non Hodgkin's lymphoma. 1997

M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
Service de Radiothérapie, Site Hospitalier Nord de Nantes, Saint-Herblain, France.

Chromosome aberrations were evaluated in the lymphocytes of 30 patients who had undergone radiotherapy several years before for non-Hodgkin's lymphoma. Twelve had received 20 Gy over the entire abdomen (group I), 12 wholebody irradiation at 1.5 Gy (group II) and 6 wholebody irradiation at 15 Gy (group III). Unirradiated patients seen for cytogenetic analysis during the same period served as controls. Overall results for the irradiated population were 13/27 (48%) evaluable patients with chromosome aberrations and 50/710 (7%) abnormal cells for a total of 73 aberrations (unstable: 35, stable: 38). The frequency of aberrations was statistically higher in group I (12% of cells) than in groups II (3.5%, p < 0.0001) and III (2.5%, p < 0.0002). Differences in irradiation dose and volume may account for the variations between groups.

UI MeSH Term Description Entries
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008224 Lymphoma, Follicular Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. Brill-Symmers Disease,Follicular Lymphoma,Lymphoma, Giant Follicular,Lymphoma, Nodular,Follicular Large-Cell Lymphoma,Follicular Lymphoma, Giant,Follicular Lymphoma, Grade 1,Follicular Lymphoma, Grade 2,Follicular Lymphoma, Grade 3,Follicular Mixed-Cell Lymphoma,Giant Follicular Lymphoma,Histiocytic Lymphoma, Nodular,Large Lymphoid Lymphoma, Nodular,Large-Cell Lymphoma, Follicular,Lymphocytic Lymphoma, Nodular, Poorly Differentiated,Lymphocytic Lymphoma, Nodular, Poorly-Differentiated,Lymphoma, Follicular Large-Cell,Lymphoma, Follicular, Grade 1,Lymphoma, Follicular, Grade 2,Lymphoma, Follicular, Grade 3,Lymphoma, Follicular, Mixed Cell,Lymphoma, Follicular, Mixed Lymphocytic-Histiocytic,Lymphoma, Follicular, Mixed Small and Large Lymphoid,Lymphoma, Follicular, Small and Large Cleaved Cell,Lymphoma, Follicular, Small and Large Cleaved-Cell,Lymphoma, Histiocytic, Nodular,Lymphoma, Large Cell, Follicular,Lymphoma, Large Lymphoid, Nodular,Lymphoma, Large-Cell, Follicular,Lymphoma, Lymphocytic, Nodular, Poorly Differentiated,Lymphoma, Lymphocytic, Nodular, Poorly-Differentiated,Lymphoma, Mixed-Cell, Follicular,Lymphoma, Nodular, Large Follicular Center Cell,Lymphoma, Nodular, Large Follicular Center-Cell,Lymphoma, Nodular, Mixed Lymphocytic Histiocytic,Lymphoma, Nodular, Mixed Lymphocytic-Histiocytic,Lymphoma, Nodular, Mixed Small and Large Cell,Lymphoma, Small Cleaved Cell, Follicular,Lymphoma, Small Cleaved-Cell, Follicular,Lymphoma, Small Follicular Center-Cell,Lymphoma, Small Lymphoid, Follicular,Mixed-Cell Lymphoma, Follicular,Nodular Large Follicular Center-Cell Lymphoma,Small Cleaved-Cell Lymphoma, Follicular,Small Follicular Center-Cell Lymphoma,Brill Symmers Disease,Disease, Brill-Symmers,Follicular Large Cell Lymphoma,Follicular Large-Cell Lymphomas,Follicular Lymphomas,Follicular Lymphomas, Giant,Follicular Mixed Cell Lymphoma,Follicular Mixed-Cell Lymphomas,Giant Follicular Lymphomas,Histiocytic Lymphomas, Nodular,Large Cell Lymphoma, Follicular,Large-Cell Lymphomas, Follicular,Lymphoma, Follicular Large Cell,Lymphoma, Follicular Mixed-Cell,Lymphoma, Nodular Histiocytic,Lymphoma, Small Follicular Center Cell,Lymphomas, Follicular,Lymphomas, Follicular Large-Cell,Lymphomas, Follicular Mixed-Cell,Lymphomas, Giant Follicular,Lymphomas, Nodular,Lymphomas, Nodular Histiocytic,Mixed Cell Lymphoma, Follicular,Mixed-Cell Lymphomas, Follicular,Nodular Histiocytic Lymphoma,Nodular Histiocytic Lymphomas,Nodular Large Follicular Center Cell Lymphoma,Nodular Lymphoma,Nodular Lymphomas,Small Cleaved Cell Lymphoma, Follicular,Small Follicular Center Cell Lymphoma
D011878 Radiotherapy The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions. Radiotherapy, Targeted,Targeted Radiotherapy,Radiation Therapy,Radiation Therapy, Targeted,Radiation Treatment,Targeted Radiation Therapy,Radiation Therapies,Radiation Therapies, Targeted,Radiation Treatments,Radiotherapies,Radiotherapies, Targeted,Targeted Radiation Therapies,Targeted Radiotherapies,Therapies, Radiation,Therapies, Targeted Radiation,Therapy, Radiation,Therapy, Targeted Radiation,Treatment, Radiation
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control

Related Publications

M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
New recurrent structural chromosome aberrations in non-Hodgkin's lymphoma.
May 1996, International journal of oncology,
M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
Non-Hodgkin's lymphoma after radiotherapy for Hodgkin's disease.
December 1979, The New England journal of medicine,
M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
[Chromosome aberrations in non-Hodgkin lymphoma and in Hodgkin's disease].
May 1992, Nederlands tijdschrift voor geneeskunde,
M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
Primary vaginal non-Hodgkin's lymphoma after radiotherapy for Hodgkin's disease.
June 2000, Australian and New Zealand journal of medicine,
M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
Normal frequency of structural chromosome aberrations in fibroblasts from patients with non-Hodgkin's lymphoma.
January 1988, Hereditas,
M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
Non-Hodgkin's lymphoma following radiotherapy for Hodgkin's disease.
September 1986, Clinical radiology,
M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
Primary rectal non-Hodgkin's lymphoma treated with radical radiotherapy.
January 1995, Clinical oncology (Royal College of Radiologists (Great Britain)),
M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
[ARDS (adult respiratory distress syndrome) after chemotherapy and radiotherapy. Complications in two patients treated for non-Hodgkin's lymphoma].
January 1995, Acta haematologica Polonica,
M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
Incidence of non-Hodgkin's lymphoma in patients treated for Hodgkin's disease.
February 1994, Leukemia & lymphoma,
M A Mahé, and M J André, and E Moyon, and A Le Mevel, and P Soubeyran, and M Hamidou, and N Milpied, and S Bourdin, and J C Cuillière, and J F Chatal
T-cell non-Hodgkin's lymphoma after radiotherapy and chemotherapy for Hodgkin's disease.
October 1981, Cancer,
Copied contents to your clipboard!