BIOMAT Database Logo BIOMAT Database Logo

Cardiovascular responses to glutamate stimulation of diagonal band of Broca. 1997

G J Kirouac, and J Ciriello
Department of Physiology, University of Western Ontario, London, Canada.

Experiments were done in alpha-chloralose-anesthetized, paralyzed, and artificially ventilated rats to investigate the effect of L-glutamate stimulation of the diagonal band of Broca (DBB) on arterial pressure (AP) and heart rate (HR). Stimulation of the horizontal limb of the DBB (hDB) elicited decreases in both mean AP (MAP; -32.3 +/- 2.5 mmHg; n = 37) and HR (-32.5 +/- 3.8 beats/min; n = 33) at 84% of the sites stimulated. Stimulation of the vertical limb of the DBB (vDB) elicited significantly smaller decreases in MAP (-9.7 +/- 1.0 mmHg; n = 19) and HR (-13.5 +/- 1.8 beats/min; n = 7) at approximately 13% of the sites stimulated. Intravenous administration of the muscarinic receptor blocker atropine methylbromide had no effect on the magnitude of the MAP and HR responses to stimulation of the hDB. In contrast, administration of the nicotinic receptor blocker hexamethonium bromide abolished both the depressor and the bradycardic responses elicited by stimulation of the hDB. These data indicate that the hDB contains neurons that exert cardiovascular depressor effects and that these circulatory effects are mediated by the inhibition of sympathetic vasoconstrictor fibers to the vasculature, and cardioacceleratory fibers to the heart.

UI MeSH Term Description Entries
D008297 Male Males
D008845 Microinjections The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes. Microinjection
D010276 Parasympatholytics Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. Antispasmodic,Antispasmodic Agent,Antispasmodic Drug,Antispasmodics,Parasympathetic-Blocking Agent,Parasympathetic-Blocking Agents,Parasympatholytic,Parasympatholytic Agent,Parasympatholytic Drug,Spasmolytic,Spasmolytics,Antispasmodic Agents,Antispasmodic Drugs,Antispasmodic Effect,Antispasmodic Effects,Parasympatholytic Agents,Parasympatholytic Drugs,Parasympatholytic Effect,Parasympatholytic Effects,Agent, Antispasmodic,Agent, Parasympathetic-Blocking,Agent, Parasympatholytic,Agents, Antispasmodic,Agents, Parasympathetic-Blocking,Agents, Parasympatholytic,Drug, Antispasmodic,Drug, Parasympatholytic,Drugs, Antispasmodic,Drugs, Parasympatholytic,Effect, Antispasmodic,Effect, Parasympatholytic,Effects, Antispasmodic,Effects, Parasympatholytic,Parasympathetic Blocking Agent,Parasympathetic Blocking Agents
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002319 Cardiovascular System The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body. Circulatory System,Cardiovascular Systems,Circulatory Systems
D002320 Cardiovascular Physiological Phenomena Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts. Cardiovascular Physiologic Processes,Cardiovascular Physiological Processes,Cardiovascular Physiology,Cardiovascular Physiological Concepts,Cardiovascular Physiological Phenomenon,Cardiovascular Physiological Process,Physiology, Cardiovascular,Cardiovascular Physiological Concept,Cardiovascular Physiological Phenomenas,Concept, Cardiovascular Physiological,Concepts, Cardiovascular Physiological,Phenomena, Cardiovascular Physiological,Phenomenon, Cardiovascular Physiological,Physiologic Processes, Cardiovascular,Physiological Concept, Cardiovascular,Physiological Concepts, Cardiovascular,Physiological Phenomena, Cardiovascular,Physiological Phenomenon, Cardiovascular,Physiological Process, Cardiovascular,Physiological Processes, Cardiovascular,Process, Cardiovascular Physiological,Processes, Cardiovascular Physiologic,Processes, Cardiovascular Physiological
D005625 Frontal Lobe The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus. Brodmann Area 8,Brodmann's Area 8,Frontal Cortex,Frontal Eye Fields,Lobus Frontalis,Supplementary Eye Field,Area 8, Brodmann,Area 8, Brodmann's,Brodmanns Area 8,Cortex, Frontal,Eye Field, Frontal,Eye Field, Supplementary,Eye Fields, Frontal,Frontal Cortices,Frontal Eye Field,Frontal Lobes,Lobe, Frontal,Supplementary Eye Fields
D005971 Glutamates Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure. Glutamic Acid Derivatives,Glutamic Acids,Glutaminic Acids
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

G J Kirouac, and J Ciriello
Interaction of GABA and glutamate in the horizontal limb of diagonal band of Broca (hDB): role in cardiovascular responses.
April 2005, Brain research,
G J Kirouac, and J Ciriello
Interaction between glutamatergic and nitrergic mechanisms mediating cardiovascular responses to L-glutamate injection in the diagonal band of Broca in anesthetized rats.
August 2007, Life sciences,
G J Kirouac, and J Ciriello
Responses in the diagonal band of Broca evoked by stimulation of the fornix in the cat.
July 1979, The Journal of physiology,
G J Kirouac, and J Ciriello
GABA and glutamate receptors in the horizontal limb of diagonal band of Broca (hDB): effects on cardiovascular regulation.
November 2005, Experimental brain research,
G J Kirouac, and J Ciriello
Pressor effects of L-glutamate injected into the diagonal band of Broca of unanesthetized rats.
January 2003, Brain research,
G J Kirouac, and J Ciriello
The diagonal band of Broca in health and disease.
January 2021, Handbook of clinical neurology,
G J Kirouac, and J Ciriello
Medial forebrain bundle projections to the nucleus of the diagonal band of Broca.
July 1975, Experientia,
G J Kirouac, and J Ciriello
Deep temporal lobe projections to the nucleus of the diagonal band of Broca.
January 1976, Experientia,
G J Kirouac, and J Ciriello
Acute hypertension increases norepinephrine release in the diagonal band of Broca.
January 1997, Brain research,
G J Kirouac, and J Ciriello
Review: Revisiting the human cholinergic nucleus of the diagonal band of Broca.
December 2018, Neuropathology and applied neurobiology,
Copied contents to your clipboard!