BIOMAT Database Logo BIOMAT Database Logo

Cyclin D1 protein expression is related to clinical progression in laryngeal squamous cell carcinomas. 1997

P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
Clinica Otorinolaringoiatrica I, Università di Milano, Ospedale Maggiore, I.R.C.C.S., Italy.

The expression of cyclin D1 gene was investigated in 74 laryngeal squamous cell carcinomas (LSCCs) in order to determine its clinical and prognostic value. Overexpression of cyclin D1 was detected immunohistochemically using DCS6 monoclonal antibody on formalin-fixed, paraffin-embedded tissue sections. Cyclin D1 expression was detected in 22 of the 74 cases investigated (30 per cent), thirteen of which presented nodal metastases (59 per cent); of the patients without any detectable cyclin D1 protein expression, six presented nodal metastases (12 per cent). Cyclin D1 protein expression was found in five per cent of the specimens of normal mucosa, eight per cent of those with low-grade dysplasia and 20 per cent of those with high-grade dysplasia. A statistically significant association was found between cyclin D1 expression and the supraglottic site (p < 0.05), tumour extension (p < 0.001), the presence of lymph node metastases (p < 0.001), and advanced clinical stage (p < 0.001). Cyclin D1 expression analysis is an important tool in the selection of LSCC patients with an aggressive clinical course.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007822 Laryngeal Neoplasms Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS. Cancer of Larynx,Laryngeal Cancer,Larynx Neoplasms,Cancer of the Larynx,Larynx Cancer,Neoplasms, Laryngeal,Cancer, Laryngeal,Cancer, Larynx,Cancers, Laryngeal,Cancers, Larynx,Laryngeal Cancers,Laryngeal Neoplasm,Larynx Cancers,Larynx Neoplasm,Neoplasm, Laryngeal,Neoplasm, Larynx,Neoplasms, Larynx
D008207 Lymphatic Metastasis Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. Lymph Node Metastasis,Lymph Node Metastases,Lymphatic Metastases,Metastasis, Lymph Node
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009363 Neoplasm Proteins Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. Proteins, Neoplasm
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D002294 Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
[Prognostic significance of cyclin D1 and cyclin B expression in laryngeal squamous cell carcinomas treated with radiotherapy].
January 2009, Otolaryngologia polska = The Polish otolaryngology,
P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
Clinical significance of Cyclin D1, FGF3 and p21 protein expression in laryngeal squamous cell carcinoma.
January 2014, Journal of B.U.ON. : official journal of the Balkan Union of Oncology,
P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
Cyclin D1 gene amplification in human laryngeal squamous cell carcinomas: prognostic significance and clinical implications.
January 1996, Clinical cancer research : an official journal of the American Association for Cancer Research,
P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
Cyclin D1 Expression in Patients with Laryngeal Squamous Cell Carcinoma.
January 2020, Iranian journal of pathology,
P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
An immunohistochemical study of cyclin D1 protein expression in laryngeal squamous cell carcinoma.
July 2007, Acta oto-laryngologica,
P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
[Clinical significance of Stat3 and Cyclin D1 expression in laryngeal squamous cell carcinoma].
November 2011, Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery,
P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
[Cyclin D1 overexpression in laryngeal carcinomas].
February 1998, Nihon Jibiinkoka Gakkai kaiho,
P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas.
April 2014, Oncology letters,
P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
Cyclin-dependent kinase inhibitor p27 is related to cell proliferation and prognosis in laryngeal squamous cell carcinomas.
May 2001, The Journal of laryngology and otology,
P Capaccio, and G Pruneri, and N Carboni, and A V Pagliari, and R Buffa, and A Neri, and A Ottaviani, and L Pignataro
[Overexpression of cyclin D1 in laryngeal carcinomas].
May 1998, Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology,
Copied contents to your clipboard!