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Interleukin-10 inhibits T-lymphocyte activation and proliferation and lipopolysaccharide-induced monocyte production of proinflammatory cytokines. Fifty-four healthy volunteers received single doses of recombinant human interleukin-10 (1.0, 2.5, 5.0, 10, 25, or 50 micrograms/kg) or placebo by subcutaneous injection (randomized double-blind assignment). Clinical adverse events were infrequent at doses below 50 micrograms/kg (five of six subjects had mild flu-like syndrome). Mean serum interleukin-10 concentrations were dose related. The mean terminal-phase half-life ranged from 2.7 to 4.5 hours, and the apparent volume of distribution ranged from 0.70 to 1.35 L/kg. Hematologic changes included transient mild to moderate increases of neutrophil counts, decreases of lymphocyte counts, and a delayed decrease of platelet counts. Recombinant human interleukin-10 significantly suppressed production of the proinflammatory cytokines interleukin-1 beta and tumor necrosis factor-alpha by whole blood stimulated ex vivo with Escherichia coli lipopolysaccharide.
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
January 1995,
Clinical pharmacology and therapeutics,
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
October 1996,
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research,
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
September 2001,
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists,
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
February 2012,
Basic & clinical pharmacology & toxicology,
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
January 2002,
Reproductive biomedicine online,
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
March 1995,
American journal of therapeutics,
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
November 1990,
Blood,
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
March 1999,
Clinical pharmacology and therapeutics,
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
February 2001,
Thrombosis research,
R D Huhn, and
E Radwanski, and
J Gallo, and
M B Affrime, and
R Sabo, and
G Gonyo, and
A Monge, and
D L Cutler
January 2001,
European cytokine network,
