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Eleven patients with Paget's disease of bone underwent serial total body bone scars before and after therapy with calcitonin. All patients studied showed improvement clinically as well as biochemically. Scan improvement was noted in patients with mild disease. Patients with severe disease showed either to change or only slight improvement on the serial bone scars The scan was of greatest value in determining the extent of disease, especially in 3 patients in whom biochemical values were normal. A single pulse injection of 50 M.R.C. units of salmon calcitonin produced a significant increase in the blood clearance of 99mTc diphosphonate. The mechanism of this effect is not clear from this study.
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
March 1976,
Lancet (London, England),
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
January 1981,
Metabolic bone disease & related research,
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
December 1981,
Schweizerische medizinische Wochenschrift,
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
February 1979,
Australian and New Zealand journal of medicine,
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
May 1984,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
August 1976,
Calcified tissue research,
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
January 1984,
Metabolic bone disease & related research,
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
January 1982,
Metabolic bone disease & related research,
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
April 1976,
Lancet (London, England),
A D Waxman, and
S Ducker, and
D McKee, and
J K Siemsen, and
F R Singer
May 1976,
Lancet (London, England),
