-transparent.png){kind=logo}
The effects of Ninjinyoeito on endothelial cells in human umbilical veins was examined. We found that Ninjinyoeito accelerates the inhibition and decomposition of Endothelin-1 production, which is known to constrict veins and raise blood pressure, and promote the synthesis of nitric oxicide which is known to have a vasophypotonic effect. We also found that Ninjinyoeito accelerates Interleukin 1-beta (IL-1 beta) production. IL-1 beta is a substance that plays important roles in maintaining the homeostasis of living organisms in immunity and inflammation, for example, as well as in the production of tissue plasminogen activators, which are known to have an anti-thrombotic effect on blood coagulation and on the fibrinolysis mechanism. Thus, it is suggested that Ninjinyoeito is effective in accelerating the physiological functions of human vein endothelial cells in vitro.
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
December 1999,
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
April 1978,
British journal of haematology,
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
December 1977,
Thrombosis research,
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
November 1997,
Artificial cells, blood substitutes, and immobilization biotechnology,
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
March 1988,
Chest,
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
April 2002,
Biochemical and biophysical research communications,
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
February 2005,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
November 2022,
Molecules (Basel, Switzerland),
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
August 1994,
The Annals of thoracic surgery,
Y Uchiyama, and
S Nakajima, and
K Yoshida, and
H Mizukawa, and
E Haruki
December 1980,
Investigative ophthalmology & visual science,
