-transparent.png){kind=logo}
Supine plasma aldosterone and plasma renin activity were determined in patients with cirrhosis of the liver and ascites (n = 10). Most of the patients initially showed an increase in plasma aldosterone and plasma renin activity. However, values within the normal range were observed (plasma aldosterone, n = 3; plasma renin activity, n = 4). In the ascitic fluid renin activity could not be detected, whereas aldosterone concentrations correlated significantly with the respective plasma levels (r = 0.8, p less than 0.01). During therapy with spironolactone alone (n =2) or in combination with furosemide (n = 4), diuresis and natriuresis showed no correlation with changes in plasma aldosterone and/or plasma renin activity. Our results suggest that other factors than renin and aldosterone secretion may be important in the formation of ascites in patients with cirrhosis of the liver. In addition, the inverse correlation between mean arterial blood pressure and plasma renin activity (r = -0.65, p less than 0.05) found in our patients supports the assumption that the increase in renin secretion is probably induced by changes in (renal) hemodynamics.
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
February 1979,
European journal of clinical investigation,
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
April 1986,
European journal of clinical investigation,
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
January 1989,
Terapevticheskii arkhiv,
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
November 1986,
Revista espanola de las enfermedades del aparato digestivo,
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
February 1967,
Sovetskaia meditsina,
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
January 1990,
Minerva medica,
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
January 1983,
Przeglad lekarski,
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
December 1984,
Gastroenterology,
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
July 1981,
Annals of internal medicine,
H Vetter, and
W Vetter, and
R Beckerhoff, and
K Glänzer, and
J Furrer, and
C Hahn, and
R Kolloch, and
F Krück, and
K Kutz, and
W Siegenthaler, and
F Witassek
December 2008,
European journal of clinical investigation,
