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Packed red cell transfusions -- improved survival, quality and storage. 1977

V A Lovric, and B Prince, and J Bryant

Various anticoagulant-preservative solutions were investigated with a view to determining which would give optimal shelf life of packed cells. Satisfactory 24-hour post-transfusion survival (greater than 70%) after 28-day storage was obtained with citrate phosphate 277 mM dextrose, 0.25 mM adenine (CP2 X D-adenine). After addition of a rejuvenating electrolyte solution through a multiple closed plastic pack system, there was further improvement in viability, oxygen delivery capacity and metabolic activity of stored erythrocytes, with reduction in both plasma potassium and microaggregate numbers. No untoward reactions were observed during or after transfusion of 440 units of rejuvenated blood.

UI MeSH Term Description Entries
D001793 Blood Preservation The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism). Blood Preservations,Preservation, Blood,Preservations, Blood
D001803 Blood Transfusion The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed) Blood Transfusions,Transfusion, Blood,Transfusions, Blood
D006400 Hematocrit The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value. Erythrocyte Volume, Packed,Packed Red-Cell Volume,Erythrocyte Volumes, Packed,Hematocrits,Packed Erythrocyte Volume,Packed Erythrocyte Volumes,Packed Red Cell Volume,Packed Red-Cell Volumes,Red-Cell Volume, Packed,Red-Cell Volumes, Packed,Volume, Packed Erythrocyte,Volume, Packed Red-Cell,Volumes, Packed Erythrocyte,Volumes, Packed Red-Cell

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