-transparent.png){kind=logo}
To investigate whether mammalian DNA topoisomerase II is directly involved in recombination events, the effects of ICRF-193, a specific catalytic inhibitor on sister chromatid exchange (SCE), were examined in MR-6 cells. ICRF-193 only slightly elevated SCE formation after 3 or 44 h treatments, while VP-16, a cleavable complex forming type of topoisomerase II inhibitor, caused significant enhancement. ICRF-193 had no effect on N-methyl-N'-nitro-N-nitrosoguanidine-induced SCE formation. It would thus appear that the inhibition of topoisomerase II does not affect recombinational repair, and that topoisomerase II inhibitors such as VP-16 and 4'-(9-acridinyl amino) methane sulfon-m-anisidide induce SCE through production of DNA strand breaks, rather than by inhibiting the enzyme activity.
M Hamatake, and
T Andoh, and
R Ishida
April 2002,
Mutation research,
M Hamatake, and
T Andoh, and
R Ishida
November 2001,
The Journal of biological chemistry,
M Hamatake, and
T Andoh, and
R Ishida
March 2015,
American journal of physiology. Cell physiology,
M Hamatake, and
T Andoh, and
R Ishida
March 2019,
The Journal of biological chemistry,
M Hamatake, and
T Andoh, and
R Ishida
February 2001,
Japanese journal of cancer research : Gann,
M Hamatake, and
T Andoh, and
R Ishida
August 2005,
EMBO reports,
M Hamatake, and
T Andoh, and
R Ishida
September 1992,
Molecular and cellular biology,
M Hamatake, and
T Andoh, and
R Ishida
May 2007,
Cell cycle (Georgetown, Tex.),
M Hamatake, and
T Andoh, and
R Ishida
August 1998,
Mutation research,
M Hamatake, and
T Andoh, and
R Ishida
March 2002,
Genes to cells : devoted to molecular & cellular mechanisms,
