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5-Fluorouracil derivatives. XXII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils. 1997
S Ozaki, and
X Kong, and
Y Watanabe, and
T Hoshiko, and
T Koga, and
T Ogasawara, and
T Takizawa, and
H Fujisawa, and
M Iigo, and
A Hoshi
Department of Chemistry, Shandong University, Jinan, China.
Fifty-four 1-carbamoyl-5-fluorouracils were synthesized from 5-fluorouracil and isocyanate or amine. Antitumor activity was tested in the L-1210 tumor system, and 11 compounds gave better values of therapeutic ratio than HCFU (1-hexylcarbamoyl-5-fluorouracil). 1-(4-Methoxycyclohexylcarbamoyl)-5-fluorouracil gave the best result.
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