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In 200 healthy test persons of either sex between 15 and 94 years the excretion of the alanine aminopeptidase (EC 3.4.11.2) and of creatinine with the urine was tested. Female test persons excrete smaller quantities of enzymes with the urine than male ones. In the two sexes the efflux of the alanine aminopeptidase only slightly increases with growing age. With regard of the enzyme activities to the creatinine in the urine the curve of excretion is clearly deformed, since in the senium significantly smaller quantities of creatinine are excreted. When an enzyme/creatinine quotient is used reference values specific to age must be used.
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